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2016 ; 8
(1
): 32-40
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English Wikipedia
Diagnostic Accuracy of Xpert Test in Tuberculosis Detection: A Systematic Review
and Meta-analysis
#MMPMID27013842
Kaur R
; Kachroo K
; Sharma JK
; Vatturi SM
; Dang A
J Glob Infect Dis
2016[Jan]; 8
(1
): 32-40
PMID27013842
show ga
BACKGROUND: World Health Organization (WHO) recommends the use of Xpert MTB/RIF
assay for rapid diagnosis of tuberculosis (TB) and detection of rifampicin
resistance. This systematic review was done to know about the diagnostic accuracy
and cost-effectiveness of the Xpert MTB/RIF assay. METHODS: A systematic
literature search was conducted in following databases: Cochrane Central Register
of Controlled Trials and Cochrane Database of Systematic Reviews, MEDLINE,
PUBMED, Scopus, Science Direct and Google Scholar for relevant studies for
studies published between 2010 and December 2014. Studies given in the systematic
reviews were accessed separately and used for analysis. Selection of studies,
data extraction and assessment of quality of included studies was performed
independently by two reviewers. Studies evaluating the diagnostic accuracy of
Xpert MTB/RIF assay among adult or predominantly adult patients (?14 years),
presumed to have pulmonary TB with or without HIV infection were included in the
review. Also, studies that had assessed the diagnostic accuracy of Xpert MTB/RIF
assay using sputum and other respiratory specimens were included. RESULTS: The
included studies had a low risk of any form of bias, showing that findings are of
high scientific validity and credibility. Quantitative analysis of 37 included
studies shows that Xpert MTB/RIF is an accurate diagnostic test for TB and
detection of rifampicin resistance. CONCLUSION: Xpert MTB/RIF assay is a robust,
sensitive and specific test for accurate diagnosis of tuberculosis as compared to
conventional tests like culture and microscopic examination.