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10.1186/s12976-016-0037-2 http://scihub22266oqcxt.onion/10.1186/s12976-016-0037-2 C4785624!4785624!26965444     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Theor+Biol+Med+Model 2016 ; 13 (ä): ä Nephropedia Template TP {{tp|p=26965444|t=2016. The organelle of differentiation in embryos: the cell state splitter |pdf=|usr=}}{{26965444}} gab.com Text The organelle of differentiation in embryos: the cell state splitter JO: Theor Biol Med Model http://www.kidney.de/pget.php?&tw=1&pmid=26965444 #FOAvip The cell state splitter is a membraneless organelle at the apical end of each epithelial cell in a developing embryo. It consists of a microfilament ring and an intermediate filament ring subtending a microtubule mat. The microtubules and microfilament ring are in mechanical opposition as in a tensegrity structure. The cell state splitter is bistable, perturbations causing it to contract or expand radially. The intermediate filament ring provides metastability against small perturbations. Once this snap-through organelle is triggered, it initiates signal transduction to the nucleus, which changes gene expression in one of two readied manners, causing its cell to undergo a step of determination and subsequent differentiation. The cell state splitter also triggers the cell state splitters of adjacent cells to respond, resulting in a differentiation wave. Embryogenesis may be represented then as a bifurcating differentiation tree, each edge representing one cell type. In combination with the differentiation waves they propagate, cell state splitters explain the spatiotemporal course of differentiation in the developing embryo. This review is excerpted from and elaborates on ?Embryogenesis Explained? (World Scientific Publishing, Singapore, 2016). Twit Text FOAVip The organelle of differentiation in embryos: the cell state splitter ????Theor Biol Med Model http://www.kidney.de/pget.php?&tw=1&pmid=26965444 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26965444 #FOAvip English Wikipedia <ref>{{Cite pmid|26965444}}</ref> The organelle of differentiation in embryos: the cell state splitter #MMPMID26965444 Gordon NK; Gordon R Theor Biol Med Model 2016[]; 13 (ä): ä PMID26965444show ga The cell state splitter is a membraneless organelle at the apical end of each epithelial cell in a developing embryo. It consists of a microfilament ring and an intermediate filament ring subtending a microtubule mat. The microtubules and microfilament ring are in mechanical opposition as in a tensegrity structure. The cell state splitter is bistable, perturbations causing it to contract or expand radially. The intermediate filament ring provides metastability against small perturbations. Once this snap-through organelle is triggered, it initiates signal transduction to the nucleus, which changes gene expression in one of two readied manners, causing its cell to undergo a step of determination and subsequent differentiation. The cell state splitter also triggers the cell state splitters of adjacent cells to respond, resulting in a differentiation wave. Embryogenesis may be represented then as a bifurcating differentiation tree, each edge representing one cell type. In combination with the differentiation waves they propagate, cell state splitters explain the spatiotemporal course of differentiation in the developing embryo. This review is excerpted from and elaborates on ?Embryogenesis Explained? (World Scientific Publishing, Singapore, 2016). äThe organelle of differentiation in embryos: the cell state splitter (epmc).pdf DeepDyve Pubget Overpricing