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2016 ; 6
(ä): 22978
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Endoscopic ultrasound-guided fine needle core biopsy for the diagnosis of
pancreatic malignant lesions: a systematic review and Meta-Analysis
#MMPMID26960914
Yang Y
; Li L
; Qu C
; Liang S
; Zeng B
; Luo Z
Sci Rep
2016[Mar]; 6
(ä): 22978
PMID26960914
show ga
Endoscopic ultrasound-guided fine needle core biopsy (EUS-FNB) has been used as
an effective method of diagnosing pancreatic malignant lesions. It has the
advantage of providing well preserved tissue for histologic grading and
subsequent molecular biological analysis. In order to estimate the diagnostic
accuracy of EUS-FNB for pancreatic malignant lesions, studies assessing EUS-FNB
to diagnose solid pancreatic masses were selected via Medline. Sixteen articles
published between 2005 and 2015, covering 828 patients, met the inclusion
criteria. The summary estimates for EUS-FNB differentiating malignant from benign
solid pancreatic masses were: sensitivity 0.84 (95% confidence interval (CI),
0.82-0.87); specificity 0.98 (95% CI, 0.93-1.00); positive likelihood ratio 8.0
(95% CI 4.5-14.4); negative likelihood ratio 0.17 (95% CI 0.10-0.26); and DOR 64
(95% CI 30.4-134.8). The area under the sROC curve was 0.96. Subgroup analysis
did not identify other factors that could substantially affect the diagnostic
accuracy, such as the study design, location of study, number of centers,
location of lesion, whether or not a cytopathologist was present, and so on.
EUS-FNB is a reliable diagnostic tool for solid pancreatic masses and should be
especially considered for pathology where histologic morphology is preferred for
diagnosis.