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2016 ; 6
(3
): e010442
Nephropedia Template TP
gab.com Text
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English Wikipedia
How do authors of systematic reviews deal with research malpractice and
misconduct in original studies? A cross-sectional analysis of systematic reviews
and survey of their authors
#MMPMID26936908
Elia N
; von Elm E
; Chatagner A
; Pöpping DM
; Tramèr MR
BMJ Open
2016[Mar]; 6
(3
): e010442
PMID26936908
show ga
OBJECTIVES: To study whether systematic reviewers apply procedures to
counter-balance some common forms of research malpractice such as not publishing
completed research, duplicate publications, or selective reporting of outcomes,
and to see whether they identify and report misconduct. DESIGN: Cross-sectional
analysis of systematic reviews and survey of their authors. PARTICIPANTS: 118
systematic reviews published in four journals (Ann Int Med, BMJ, JAMA, Lancet),
and the Cochrane Library, in 2013. MAIN OUTCOMES AND MEASURES: Number (%) of
reviews that applied procedures to reduce the impact of: (1) publication bias
(through searching of unpublished trials), (2) selective outcome reporting (by
contacting the authors of the original studies), (3) duplicate publications, (4)
sponsors' and (5) authors' conflicts of interest, on the conclusions of the
review, and (6) looked for ethical approval of the studies. Number (%) of
reviewers who suspected misconduct are reported. The procedures applied were
compared across journals. RESULTS: 80 (68%) reviewers confirmed their data. 59
(50%) reviews applied three or more procedures; 11 (9%) applied none. Unpublished
trials were searched in 79 (66%) reviews. Authors of original studies were
contacted in 73 (62%). Duplicate publications were searched in 81 (69%). 27
reviews (23%) reported sponsors of the included studies; 6 (5%) analysed their
impact on the conclusions of the review. Five reviews (4%) looked at conflicts of
interest of study authors; none of them analysed their impact. Three reviews
(2.5%) looked at ethical approval of the studies. Seven reviews (6%) suspected
misconduct; only 2 (2%) reported it explicitly. Procedures applied differed
across the journals. CONCLUSIONS: Only half of the systematic reviews applied
three or more of the six procedures examined. Sponsors, conflicts of interest of
authors and ethical approval remain overlooked. Research misconduct is sometimes
identified, but rarely reported. Guidance on when, and how, to report suspected
misconduct is needed.