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10.1038/ncomms10823 http://scihub22266oqcxt.onion/10.1038/ncomms10823 C4785227!4785227 !26940455     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26940455 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 10823 Nephropedia Template TP {{tp|p=26940455 |t=2016. Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse |pdf=|usr=}}{{26940455 }} gab.com Text Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26940455 #FOAvip Human melanoma cells express various tumour antigens that are recognized by CD8(+) cytotoxic T lymphocytes (CTLs) and elicit tumour-specific responses in vivo. However, natural and therapeutically enhanced CTL responses in melanoma patients are of limited efficacy. The mechanisms underlying CTL effector phase failure when facing melanomas are still largely elusive. Here we show that, on conjugation with CTL, human melanoma cells undergo an active late endosome/lysosome trafficking, which is intensified at the lytic synapse and is paralleled by cathepsin-mediated perforin degradation and deficient granzyme B penetration. Abortion of SNAP-23-dependent lysosomal trafficking, pH perturbation or impairment of lysosomal proteolytic activity restores susceptibility to CTL attack. Inside the arsenal of melanoma cell strategies to escape immune surveillance, we identify a self-defence mechanism based on exacerbated lysosome secretion and perforin degradation at the lytic synapse. Interfering with this synaptic self-defence mechanism might be useful in potentiating CTL-mediated therapies in melanoma patients. Twit Text FOAVip Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26940455 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26940455 #FOAvip English Wikipedia <ref>{{Cite pmid|26940455 }}</ref> Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse #MMPMID26940455 Khazen R ; Müller S ; Gaudenzio N ; Espinosa E ; Puissegur MP ; Valitutti S Nat Commun 2016[Mar]; 7 (ä): 10823 PMID26940455 show ga Human melanoma cells express various tumour antigens that are recognized by CD8(+) cytotoxic T lymphocytes (CTLs) and elicit tumour-specific responses in vivo. However, natural and therapeutically enhanced CTL responses in melanoma patients are of limited efficacy. The mechanisms underlying CTL effector phase failure when facing melanomas are still largely elusive. Here we show that, on conjugation with CTL, human melanoma cells undergo an active late endosome/lysosome trafficking, which is intensified at the lytic synapse and is paralleled by cathepsin-mediated perforin degradation and deficient granzyme B penetration. Abortion of SNAP-23-dependent lysosomal trafficking, pH perturbation or impairment of lysosomal proteolytic activity restores susceptibility to CTL attack. Inside the arsenal of melanoma cell strategies to escape immune surveillance, we identify a self-defence mechanism based on exacerbated lysosome secretion and perforin degradation at the lytic synapse. Interfering with this synaptic self-defence mechanism might be useful in potentiating CTL-mediated therapies in melanoma patients. |CD8-Positive T-Lymphocytes/metabolism/*physiology [MESH] |Cathepsins/metabolism [MESH] |Cell Line [MESH] |Cytotoxicity, Immunologic/*physiology [MESH] |Endosomes/physiology [MESH] |Gene Expression Regulation, Neoplastic/physiology [MESH] |Humans [MESH] |Hydrogen-Ion Concentration [MESH] |Lymphocyte Activation [MESH] |Lysosomes/*metabolism [MESH] |Melanoma/*metabolism [MESH] |Perforin/genetics/metabolism [MESH] |Protein Transport [MESH] |Qb-SNARE Proteins/genetics/metabolism [MESH]Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cy(epmc).pdf DeepDyve Pubget Overpricing