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10.1038/mi.2015.95 http://scihub22266oqcxt.onion/10.1038/mi.2015.95 C4785101!4785101 !26349661     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26349661 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mucosal+Immunol 2016 ; 9 (3 ): 718-29 Nephropedia Template TP {{tp|p=26349661 |t=2016. IFN-? induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense |pdf=|usr=}}{{26349661 }} gab.com Text IFN- induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense JO: Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26349661 #FOAvip The role of interleukin-17A (IL-17A) in host defense against Legionella pneumophila remains elusive. To address this issue, we used Il17a(-/-), Il17f(-/-), and Il17a/Il17f(-/-) mice on a C57Bl/6 (non-permissive) background and IL-17 neutralizing Abs in mice on an A/J (permissive) background. Higher bacterial (L. pneumophila) counts in the lung and blood along with reduced neutrophil recruitment were detected in Il17a(-/-), but not Il17f(-/-), mice. We found that neutrophils produce IL-17A homodimer (IL-17A) during L. pneumophila infection, and hematopoietic cell-derived IL-17A is known to be important for bacterial clearance. Thus, intratracheal administration of wild-type neutrophils or recombinant IL-17A restored bacterial clearance and neutrophil recruitment in Il17a(-/-) mice. Furthermore, neutrophil-depleted Rag2(-/-) and Rag2/Il-2r?(-/-) mice exhibited increased bacterial burden, reduced neutrophil influx and IL-17A production in the lung. Recombinant IFN-? administration in Il17a(-/-) mice augmented bacterial elimination, whereas IL-17A administration in Ifn?(-/-) mice did not augment bacterial clearance. IFN-? is produced by T cells, but not neutrophils or macrophages, suggesting that neutrophil-derived IL-17A induces IFN-? in a paracrine fashion. Human pneumonic lungs and human neutrophils challenged with L. pneumophila exhibited increased numbers of IL-17A producing cells. These findings display a novel function of neutrophil-derived IL-17A in antibacterial defense via the induction of IFN-? in a paracrine manner. Twit Text FOAVip IFN- induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense ????Mucosal Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26349661 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26349661 #FOAvip English Wikipedia <ref>{{Cite pmid|26349661 }}</ref> IFN-? induction by neutrophil-derived IL-17A homodimer augments pulmonary antibacterial defense #MMPMID26349661 Cai S ; Batra S ; Langohr I ; Iwakura Y ; Jeyaseelan S Mucosal Immunol 2016[May]; 9 (3 ): 718-29 PMID26349661 show ga The role of interleukin-17A (IL-17A) in host defense against Legionella pneumophila remains elusive. To address this issue, we used Il17a(-/-), Il17f(-/-), and Il17a/Il17f(-/-) mice on a C57Bl/6 (non-permissive) background and IL-17 neutralizing Abs in mice on an A/J (permissive) background. Higher bacterial (L. pneumophila) counts in the lung and blood along with reduced neutrophil recruitment were detected in Il17a(-/-), but not Il17f(-/-), mice. We found that neutrophils produce IL-17A homodimer (IL-17A) during L. pneumophila infection, and hematopoietic cell-derived IL-17A is known to be important for bacterial clearance. Thus, intratracheal administration of wild-type neutrophils or recombinant IL-17A restored bacterial clearance and neutrophil recruitment in Il17a(-/-) mice. Furthermore, neutrophil-depleted Rag2(-/-) and Rag2/Il-2r?(-/-) mice exhibited increased bacterial burden, reduced neutrophil influx and IL-17A production in the lung. Recombinant IFN-? administration in Il17a(-/-) mice augmented bacterial elimination, whereas IL-17A administration in Ifn?(-/-) mice did not augment bacterial clearance. IFN-? is produced by T cells, but not neutrophils or macrophages, suggesting that neutrophil-derived IL-17A induces IFN-? in a paracrine fashion. Human pneumonic lungs and human neutrophils challenged with L. pneumophila exhibited increased numbers of IL-17A producing cells. These findings display a novel function of neutrophil-derived IL-17A in antibacterial defense via the induction of IFN-? in a paracrine manner. |Animals [MESH] |Antibodies, Neutralizing/administration & dosage [MESH] |Bacterial Load [MESH] |Cells, Cultured [MESH] |Dimerization [MESH] |Female [MESH] |Humans [MESH] |Interferon-gamma/genetics/*metabolism [MESH] |Interleukin-17/genetics/immunology/*metabolism [MESH] |Legionella pneumophila/*immunology [MESH] |Legionnaires' Disease/*immunology [MESH] |Lung/*immunology/microbiology [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Neutrophil Infiltration [MESH] |Neutrophils/*immunology/microbiology [MESH]IFN-? induction by neutrophil-derived IL-17A homodimer augments pulmon(epmc).pdf DeepDyve Pubget Overpricing