Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1177/1740774515614542 http://scihub22266oqcxt.onion/10.1177/1740774515614542 C4785046!4785046!26572562     free     free     free       Clin+Trials 2016 ; 13 (2): 188-98 Nephropedia Template TP {{tp|p=26572562|t=2016. Sample Size Under the Additive Hazards Model |pdf=|usr=}}{{26572562}} gab.com Text Sample Size Under the Additive Hazards Model JO: Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=26572562 #FOAvip Background: The additive hazards model can be easier to interpret and in some cases fits better than the proportional hazards model. However, sample size formulas for clinical trials with time to event outcomes are currently based on either the proportional hazards assumption or an assumption of constant hazards. Aims: The goal is to provide sample size formulas for superiority and non-inferiority trials assuming an additive hazards model but no specific distribution, along with evaluations of the performance of the formulas. Methods: Formulas are presented that determine the required sample size for a given scenario under the additive hazards model. Simulations are conducted to ensure that the formulas attain the desired power. For illustration, the non-inferiority sample size formula is applied to the calculations in the SPORTIF III trial of stroke prevention in atrial fibrillation. Conclusions: Simulation results show that the sample size calculations lead to the correct power. Sample size is easily calculated using a tool that is available on the web at http://leemcdaniel.github.io/samplesize.html. Twit Text FOAVip Sample Size Under the Additive Hazards Model ????Clin Trials http://www.kidney.de/pget.php?&tw=1&pmid=26572562 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26572562 #FOAvip English Wikipedia <ref>{{Cite pmid|26572562}}</ref> Sample Size Under the Additive Hazards Model #MMPMID26572562 McDaniel LS; Yu M; Chappell R Clin Trials 2016[Apr]; 13 (2): 188-98 PMID26572562show ga Background: The additive hazards model can be easier to interpret and in some cases fits better than the proportional hazards model. However, sample size formulas for clinical trials with time to event outcomes are currently based on either the proportional hazards assumption or an assumption of constant hazards. Aims: The goal is to provide sample size formulas for superiority and non-inferiority trials assuming an additive hazards model but no specific distribution, along with evaluations of the performance of the formulas. Methods: Formulas are presented that determine the required sample size for a given scenario under the additive hazards model. Simulations are conducted to ensure that the formulas attain the desired power. For illustration, the non-inferiority sample size formula is applied to the calculations in the SPORTIF III trial of stroke prevention in atrial fibrillation. Conclusions: Simulation results show that the sample size calculations lead to the correct power. Sample size is easily calculated using a tool that is available on the web at http://leemcdaniel.github.io/samplesize.html. äSample Size Under the Additive Hazards Model (epmc).pdf DeepDyve Pubget Overpricing