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10.4049/jimmunol.1500139 http://scihub22266oqcxt.onion/10.4049/jimmunol.1500139 C4784714!4784714!26246140     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 251.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2015 ; 195 (6): 2648-56 Nephropedia Template TP {{tp|p=26246140|t=2015. Hepatic stellate cells inhibit T cells through active TGF?1 from a cell-surface-bound latent TGF?1/GARP complex |pdf=|usr=}}{{26246140}} gab.com Text Hepatic stellate cells inhibit T cells through active TGF 1 from a cell-surface-bound latent TGF 1/GARP complex JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26246140 #FOAvip Hepatic stellate cells (HSCs) inhibit T cells, a process that could help the liver to maintain its immunoprivileged status. HSCs secrete latent TGF?1, but the detailed mechanisms by which latent TGF?1 is activated and whether it plays any role in HSC-mediated T-cell suppression remain unclear. Glycoprotein A repetitions predominant (GARP) is a surface marker of activated regulatory T cells (Tregs). GARP binds latent TGF?1 for its activation, which is critical for Tregs to suppress effector T cells; however, it is still unclear whether GARP is present on HSCs and whether it has any impact on HSC function. In this study, we found that TGF?1+/? HSCs, which produce reduced levels of TGF?1, showed decreased potency in inhibiting T cells. We also found that pharmaceutical or genetic inhibition of the TGF?1 signaling pathway reduced the T-cell-inhibiting activity of HSCs. In addition, using isolated primary HSCs, we demonstrated that GARP was constitutively expressed on HSCs. Blocking GARP function or knocking down GARP expression significantly impaired the potency of HSCs to suppress the proliferation of and IFN? production from activated T cells, suggesting that GARP is important for HSCs to inhibit T cells. These results demonstrate the unexpected presence of GARP on HSCs and its significance in regard to the ability of HSCs to activate latent TGF?1 and thereby inhibit T cells. Our study reveals a new mechanism for HSC-mediated immune regulation and potentially for other conditions, such as liver fibrosis, that involve HSC-secreted TGF?1. Twit Text FOAVip Hepatic stellate cells inhibit T cells through active TGF 1 from a cell-surface-bound latent TGF 1/GARP complex ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26246140 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26246140 #FOAvip English Wikipedia <ref>{{Cite pmid|26246140}}</ref> Hepatic stellate cells inhibit T cells through active TGF?1 from a cell-surface-bound latent TGF?1/GARP complex #MMPMID26246140 Li Y; Kim BG; Qian S; Letterio JJ; Fung JJ; Lu L; Lin F J Immunol 2015[Sep]; 195 (6): 2648-56 PMID26246140show ga Hepatic stellate cells (HSCs) inhibit T cells, a process that could help the liver to maintain its immunoprivileged status. HSCs secrete latent TGF?1, but the detailed mechanisms by which latent TGF?1 is activated and whether it plays any role in HSC-mediated T-cell suppression remain unclear. Glycoprotein A repetitions predominant (GARP) is a surface marker of activated regulatory T cells (Tregs). GARP binds latent TGF?1 for its activation, which is critical for Tregs to suppress effector T cells; however, it is still unclear whether GARP is present on HSCs and whether it has any impact on HSC function. In this study, we found that TGF?1+/? HSCs, which produce reduced levels of TGF?1, showed decreased potency in inhibiting T cells. We also found that pharmaceutical or genetic inhibition of the TGF?1 signaling pathway reduced the T-cell-inhibiting activity of HSCs. In addition, using isolated primary HSCs, we demonstrated that GARP was constitutively expressed on HSCs. Blocking GARP function or knocking down GARP expression significantly impaired the potency of HSCs to suppress the proliferation of and IFN? production from activated T cells, suggesting that GARP is important for HSCs to inhibit T cells. These results demonstrate the unexpected presence of GARP on HSCs and its significance in regard to the ability of HSCs to activate latent TGF?1 and thereby inhibit T cells. Our study reveals a new mechanism for HSC-mediated immune regulation and potentially for other conditions, such as liver fibrosis, that involve HSC-secreted TGF?1. äHepatic stellate cells inhibit T cells through active TGF?1 from a cel(epmc).pdf DeepDyve Pubget Overpricing