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Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 J+Hematol+Oncol 2016 ; 9 (ä): ä Nephropedia Template TP
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Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor #MMPMID26957112
Wu J; Zhang M; Liu D
J Hematol Oncol 2016[]; 9 (ä): ä PMID26957112show ga
More and more targeted agents become available for B cell malignancies with increasing precision and potency. The first-in-class Bruton?s tyrosine kinase (BTK) inhibitor, ibrutinib, has been in clinical use for the treatment of chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom?s macroglobulinemia. More selective BTK inhibitors (ACP-196, ONO/GS-4059, BGB-3111, CC-292) are being explored. Acalabrutinib (ACP-196) is a novel irreversible second-generation BTK inhibitor that was shown to be more potent and selective than ibrutinib. This review summarized the preclinical research and clinical data of acalabrutinib.