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10.1186/s13045-016-0250-9

http://scihub22266oqcxt.onion/10.1186/s13045-016-0250-9
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C4784459!4784459!26957112
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suck abstract from ncbi


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pmid26957112      J+Hematol+Oncol 2016 ; 9 (ä): ä
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  • Acalabrutinib (ACP-196): a selective second-generation BTK inhibitor #MMPMID26957112
  • Wu J; Zhang M; Liu D
  • J Hematol Oncol 2016[]; 9 (ä): ä PMID26957112show ga
  • More and more targeted agents become available for B cell malignancies with increasing precision and potency. The first-in-class Bruton?s tyrosine kinase (BTK) inhibitor, ibrutinib, has been in clinical use for the treatment of chronic lymphocytic leukemia, mantle cell lymphoma, and Waldenstrom?s macroglobulinemia. More selective BTK inhibitors (ACP-196, ONO/GS-4059, BGB-3111, CC-292) are being explored. Acalabrutinib (ACP-196) is a novel irreversible second-generation BTK inhibitor that was shown to be more potent and selective than ibrutinib. This review summarized the preclinical research and clinical data of acalabrutinib.
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