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10.1186/s13000-016-0475-5 http://scihub22266oqcxt.onion/10.1186/s13000-016-0475-5 C4784347!4784347!26961851     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 269.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Diagn+Pathol 2016 ; 11 (ä): ä Nephropedia Template TP {{tp|p=26961851|t=2016. Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis |pdf=|usr=}}{{26961851}} gab.com Text Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis JO: Diagn Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26961851 #FOAvip Background: Four subtypes of hepatocellular adenomas (HCA) are recognized: hepatocyte-nuclear-factor-1? mutated (H-HCA), ?-catenin-mutated type with upregulation of glutamine synthetase (b-HCA), inflammatory type (IHCA) with serum-amyloid-A overexpression, and unclassified type. Subtyping may be useful since b-HCA appear to have higher risk of malignant transformation. We sought to apply subtype analysis and assess histological atypia, correlating these with next-generation sequencing analysis. Methods: Twenty-six HCA were stained with serum amyloid A (SAA), liver fatty acid-binding protein (LFABP), glutamine synthetase (GS), and ?-catenin IHC, followed by analysis with a targeted multiplex sequencing panel. Results: By IHC, 4 HCA (15.4 %) were classified as b-HCA, 11 (42.3 %) as IHCA, 9 (34.6 %) as H-HCA, and two (7.7 %) unclassifiable. Eight HCA (30.8 %) showed atypia (3 b-HCA, 4 IHCA and 1 H-HCA). Targeted sequencing confirmed HNF1A mutations in all H-HCA, confirming reliability of LFABP IHC in identifying these lesions. CTNNB1 mutations were detected in 1 of 4 (25 %) of GS/?-catenin-positive cases, suggesting that positive GS stain does not always correlate with CTNNB1 mutations. Conclusions: Immunohistochemistry does not consistently identify b-HCA. Mutational analysis improves the diagnostic accuracy of ?-catenin-mutated HCA and is an important tool to assess risk of malignancy in HCA. Twit Text FOAVip Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis ????Diagn Pathol http://www.kidney.de/pget.php?&tw=1&pmid=26961851 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26961851 #FOAvip English Wikipedia <ref>{{Cite pmid|26961851}}</ref> Hepatocellular adenoma classification: a comparative evaluation of immunohistochemistry and targeted mutational analysis #MMPMID26961851 Margolskee E; Bao F; de Gonzalez AK; Moreira RK; Lagana S; Sireci AN; Sepulveda AR; Remotti H; Lefkowitch JH; Salomao M Diagn Pathol 2016[]; 11 (ä): ä PMID26961851show ga Background: Four subtypes of hepatocellular adenomas (HCA) are recognized: hepatocyte-nuclear-factor-1? mutated (H-HCA), ?-catenin-mutated type with upregulation of glutamine synthetase (b-HCA), inflammatory type (IHCA) with serum-amyloid-A overexpression, and unclassified type. Subtyping may be useful since b-HCA appear to have higher risk of malignant transformation. We sought to apply subtype analysis and assess histological atypia, correlating these with next-generation sequencing analysis. Methods: Twenty-six HCA were stained with serum amyloid A (SAA), liver fatty acid-binding protein (LFABP), glutamine synthetase (GS), and ?-catenin IHC, followed by analysis with a targeted multiplex sequencing panel. Results: By IHC, 4 HCA (15.4 %) were classified as b-HCA, 11 (42.3 %) as IHCA, 9 (34.6 %) as H-HCA, and two (7.7 %) unclassifiable. Eight HCA (30.8 %) showed atypia (3 b-HCA, 4 IHCA and 1 H-HCA). Targeted sequencing confirmed HNF1A mutations in all H-HCA, confirming reliability of LFABP IHC in identifying these lesions. CTNNB1 mutations were detected in 1 of 4 (25 %) of GS/?-catenin-positive cases, suggesting that positive GS stain does not always correlate with CTNNB1 mutations. Conclusions: Immunohistochemistry does not consistently identify b-HCA. Mutational analysis improves the diagnostic accuracy of ?-catenin-mutated HCA and is an important tool to assess risk of malignancy in HCA. äHepatocellular adenoma classification: a comparative evaluation of imm(epmc).pdf DeepDyve Pubget Overpricing