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10.1177/1756285615621687

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suck abstract from ncbi


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pmid27006696      Ther+Adv+Neurol+Disord 2016 ; 9 (2): 85-94
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  • Nontraumatic spinal cord injury at the neurological intensive care unit: spectrum, causes of admission and predictors of mortality #MMPMID27006696
  • Grassner L; Marschallinger J; Dünser MW; Novak HF; Zerbs A; Aigner L; Trinka E; Sellner J
  • Ther Adv Neurol Disord 2016[Mar]; 9 (2): 85-94 PMID27006696show ga
  • Objective:: Nontraumatic spinal cord injuries (NTSCIs) form a heterogeneous group of diseases, which may evolve into a life-threatening condition. We sought to characterize spectrum, causes of admission and predictors of death in patients with NTSCI treated at the neurological intensive care unit (NICU). Methods:: We performed a retrospective observational analysis of NTSCI cases treated at a tertiary care center between 2001 and 2013. Among the 3937 NICU admissions were 93 patients with NTSCI (2.4%). Using multivariate logistic regression analysis, we examined predictors of mortality including demographics, etiology, reasons for admission and GCS/SAPS (Glasgow Coma Scale/Simplified Acute Physiology Score) scores. Results:: Infectious and inflammatory/autoimmune causes made up 50% of the NTSCI cases. The most common reasons for NICU admission were rapidly progressing paresis (49.5%) and abundance of respiratory insufficiency (26.9%). The mortality rate was 22.6% and 2.5-fold higher than in the cohort of all other patients treated at the NICU. Respiratory insufficiency as the reason for NICU admission [odds ratio (OR) 4.97, 95% confidence interval (CI) 1.38?17.9; p < 0.01], high initial SAPS scores (OR 1.04; 95% CI 1.003?1.08; p = 0.04), and the development of acute kidney injury throughout the stay (OR 7.25, 1.9?27.5; p = 0.004) were independent risk factors for NICU death. Conclusions:: Patients with NTSCI account for a subset of patients admitted to the NICU and are at risk for adverse outcome. A better understanding of predisposing conditions and further knowledge of management of critically ill patients with NTSCI is mandatory.
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