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10.4103/1947-2714.175206

http://scihub22266oqcxt.onion/10.4103/1947-2714.175206
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C4784182!4784182!27011946
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suck abstract from ncbi


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pmid27011946      N+Am+J+Med+Sci 2016 ; 8 (1): 40-6
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  • The Pathogenesis of Rheumatoid Arthritis is Associated with Milk or Egg Allergy #MMPMID27011946
  • Li J; Yan H; Chen H; Ji Q; Huang S; Yang P; Liu Z; Yang B
  • N Am J Med Sci 2016[Jan]; 8 (1): 40-6 PMID27011946show ga
  • Background:: Rheumatoid arthritis (RA) is a very complicated autoimmune disease with apparent synovial hyperplasia and cartilage and bone destruction. Aims:: In the present study, we aimed to determine whether the pathogenesis of RA correlates with food allergy and which allergen(s) are relevant. Materials and Methods:: We used type-II collagen (CII) to induce arthritis (collagen-induced arthritis, CIA) model in Wistar rats, and the development of arthritis was evaluated accordingly by scoring system. Proinflammatory cytokine levels in plasma were measured by enzyme-linked immunosorbent assay (ELISA), and concentrations of circulating immune complexes (CICs) were analyzed by C1q solid phase method. Furthermore, food-specific immunoglobulin G (IgG) and immunoglobulin E (IgE) levels were determined in the CIA model. Results:: In the CIA model, we found that levels of tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1, IL-6, and IL-17, as well as CICs, were elevated significantly. Moreover, concentrations of milk- or egg-specific IgG and IgE were enhanced strikingly in CIA rats. Conclusion:: The results suggest that pathogenesis of RA correlates closely to increased egg- or milk-specific antibodies.
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