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Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 N+Am+J+Med+Sci 2016 ; 8 (1): 40-6 Nephropedia Template TP
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The Pathogenesis of Rheumatoid Arthritis is Associated with Milk or Egg Allergy #MMPMID27011946
Li J; Yan H; Chen H; Ji Q; Huang S; Yang P; Liu Z; Yang B
N Am J Med Sci 2016[Jan]; 8 (1): 40-6 PMID27011946show ga
Background:: Rheumatoid arthritis (RA) is a very complicated autoimmune disease with apparent synovial hyperplasia and cartilage and bone destruction. Aims:: In the present study, we aimed to determine whether the pathogenesis of RA correlates with food allergy and which allergen(s) are relevant. Materials and Methods:: We used type-II collagen (CII) to induce arthritis (collagen-induced arthritis, CIA) model in Wistar rats, and the development of arthritis was evaluated accordingly by scoring system. Proinflammatory cytokine levels in plasma were measured by enzyme-linked immunosorbent assay (ELISA), and concentrations of circulating immune complexes (CICs) were analyzed by C1q solid phase method. Furthermore, food-specific immunoglobulin G (IgG) and immunoglobulin E (IgE) levels were determined in the CIA model. Results:: In the CIA model, we found that levels of tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1, IL-6, and IL-17, as well as CICs, were elevated significantly. Moreover, concentrations of milk- or egg-specific IgG and IgE were enhanced strikingly in CIA rats. Conclusion:: The results suggest that pathogenesis of RA correlates closely to increased egg- or milk-specific antibodies.