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2016 ; 17
(2
): 201
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English Wikipedia
Drug-Induced Liver Injury Network Causality Assessment: Criteria and Experience
in the United States
#MMPMID26861284
Hayashi PH
Int J Mol Sci
2016[Feb]; 17
(2
): 201
PMID26861284
show ga
Hepatotoxicity due to drugs, herbal or dietary supplements remains largely a
clinical diagnosis based on meticulous history taking and exclusion of other
causes of liver injury. In 2004, the U.S. Drug-Induced Liver Injury Network
(DILIN) was created under the auspices of the U.S. National Institute of Diabetes
and Digestive and Kidney Diseases with the aims of establishing a large registry
of cases for clinical, epidemiological and mechanistic study. From inception, the
DILIN has used an expert opinion process that incorporates consensus amongst
three different DILIN hepatologists assigned to each case. It is the most
well-established, well-described and vigorous expert opinion process for DILI to
date, and yet it is an imperfect standard. This review will discuss the DILIN
expert opinion process, its strengths and weaknesses, psychometric performance
and future.
|Chemical and Drug Induced Liver Injury/*diagnosis/etiology
[MESH]
|Consensus
[MESH]
|Drug-Related Side Effects and Adverse Reactions/*diagnosis
[MESH]