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10.3390/ijms17020175

http://scihub22266oqcxt.onion/10.3390/ijms17020175
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C4783909!4783909!26861306
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suck abstract from ncbi


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pmid26861306      Int+J+Mol+Sci 2016 ; 17 (2): ä
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  • Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer #MMPMID26861306
  • Ciardiello C; Cavallini L; Spinelli C; Yang J; Reis-Sobreiro M; de Candia P; Minciacchi VR; Di Vizio D
  • Int J Mol Sci 2016[Feb]; 17 (2): ä PMID26861306show ga
  • Extracellular Vesicles (EVs) have received considerable attention in recent years, both as mediators of intercellular communication pathways that lead to tumor progression, and as potential sources for discovery of novel cancer biomarkers. For many years, research on EVs has mainly investigated either the mechanism of biogenesis and cargo selection and incorporation, or the methods of EV isolation from available body fluids for biomarker discovery. Recent studies have highlighted the existence of different populations of cancer-derived EVs, with distinct molecular cargo, thus pointing to the possibility that the various EV populations might play diverse roles in cancer and that this does not happen randomly. However, data attributing cancer specific intercellular functions to given populations of EVs are still limited. A deeper functional, biochemical and molecular characterization of the various EV classes might identify more selective clinical markers, and significantly advance our knowledge of the pathogenesis and disease progression of many cancer types.
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