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Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Int+J+Mol+Sci 2016 ; 17 (2): ä Nephropedia Template TP
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Focus on Extracellular Vesicles: Development of Extracellular Vesicle-Based Therapeutic Systems #MMPMID26861303
Ohno Si; Drummen GPC; Kuroda M
Int J Mol Sci 2016[Feb]; 17 (2): ä PMID26861303show ga
Many types of cells release phospholipid membrane vesicles thought to play key roles in cell-cell communication, antigen presentation, and the spread of infectious agents. Extracellular vesicles (EVs) carry various proteins, messenger RNAs (mRNAs), and microRNAs (miRNAs), like a ?message in a bottle? to cells in remote locations. The encapsulated molecules are protected from multiple types of degradative enzymes in body fluids, making EVs ideal for delivering drugs. This review presents an overview of the potential roles of EVs as natural drugs and novel drug-delivery systems.