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10.3390/ijms17020171 http://scihub22266oqcxt.onion/10.3390/ijms17020171 C4783905!4783905 !26861302     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26861302 &cmd=llinks): Failed to open stream: HTTP request failed! 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Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles |pdf=|usr=}}{{26861302 }} gab.com Text Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26861302 #FOAvip Extracellular vesicles (EVs) are a heterogeneous population of secreted membrane vesicles, with distinct biogenesis routes, biophysical properties and different functions both in physiological conditions and in disease. The release of EVs is a widespread biological process, which is conserved across species. In recent years, numerous studies have demonstrated that several bioactive molecules are trafficked with(in) EVs, such as microRNAs, mRNAs, proteins and lipids. The understanding of their final impact on the biology of specific target cells remains matter of intense debate in the field. Also, EVs have attracted great interest as potential novel cell-free therapeutics. Here we describe the proposed physiological and pathological functions of EVs, with a particular focus on their molecular content. Also, we discuss the advances in the knowledge of the mechanisms regulating the secretion of EV-associated molecules and the specific pathways activated upon interaction with the target cell, highlighting the role of EVs in the context of the immune system and as mediators of the intercellular signalling in the brain. Twit Text FOAVip Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26861302 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26861302 #FOAvip English Wikipedia <ref>{{Cite pmid|26861302 }}</ref> Focus on Extracellular Vesicles: Physiological Role and Signalling Properties of Extracellular Membrane Vesicles #MMPMID26861302 Iraci N ; Leonardi T ; Gessler F ; Vega B ; Pluchino S Int J Mol Sci 2016[Feb]; 17 (2 ): 171 PMID26861302 show ga Extracellular vesicles (EVs) are a heterogeneous population of secreted membrane vesicles, with distinct biogenesis routes, biophysical properties and different functions both in physiological conditions and in disease. The release of EVs is a widespread biological process, which is conserved across species. In recent years, numerous studies have demonstrated that several bioactive molecules are trafficked with(in) EVs, such as microRNAs, mRNAs, proteins and lipids. The understanding of their final impact on the biology of specific target cells remains matter of intense debate in the field. Also, EVs have attracted great interest as potential novel cell-free therapeutics. Here we describe the proposed physiological and pathological functions of EVs, with a particular focus on their molecular content. Also, we discuss the advances in the knowledge of the mechanisms regulating the secretion of EV-associated molecules and the specific pathways activated upon interaction with the target cell, highlighting the role of EVs in the context of the immune system and as mediators of the intercellular signalling in the brain. |*Cell Communication [MESH] |*Signal Transduction [MESH] |Animals [MESH] |Biological Transport [MESH] |Cell Transformation, Neoplastic/genetics/metabolism [MESH] |Disease Susceptibility [MESH] |Drug Delivery Systems [MESH] |Exosomes/genetics/metabolism [MESH] |Extracellular Vesicles/genetics/*metabolism [MESH] |Humans [MESH] |Immunomodulation [MESH] |Proteins/genetics/metabolism [MESH]Focus on Extracellular Vesicles: Physiological Role and Signalling Pro(epmc).pdf DeepDyve Pubget Overpricing