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10.3390/ijms17020170 http://scihub22266oqcxt.onion/10.3390/ijms17020170 C4783904!4783904!26861301     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2016 ; 17 (2): ä Nephropedia Template TP {{tp|p=26861301|t=2016. Focus on Extracellular Vesicles: Introducing the Next Small Big Thing |pdf=|usr=}}{{26861301}} gab.com Text Focus on Extracellular Vesicles: Introducing the Next Small Big Thing JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26861301 #FOAvip Intercellular communication was long thought to be regulated exclusively through direct contact between cells or via release of soluble molecules that transmit the signal by binding to a suitable receptor on the target cell, and/or via uptake into that cell. With the discovery of small secreted vesicular structures that contain complex cargo, both in their lumen and the lipid membrane that surrounds them, a new frontier of signal transduction was discovered. These ?extracellular vesicles? (EV) were initially thought to be garbage bags through which the cell ejected its waste. Whilst this is a major function of one type of EV, i.e., apoptotic bodies, many EVs have intricate functions in intercellular communication and compound exchange; although their physiological roles are still ill-defined. Additionally, it is now becoming increasingly clear that EVs mediate disease progression and therefore studying EVs has ignited significant interests among researchers from various fields of life sciences. Consequently, the research effort into the pathogenic roles of EVs is significantly higher even though their protective roles are not well established. The ?Focus on extracellular vesicles? series of reviews highlights the current state of the art regarding various topics in EV research, whilst this review serves as an introductory overview of EVs, their biogenesis and molecular composition. Twit Text FOAVip Focus on Extracellular Vesicles: Introducing the Next Small Big Thing ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26861301 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26861301 #FOAvip English Wikipedia <ref>{{Cite pmid|26861301}}</ref> Focus on Extracellular Vesicles: Introducing the Next Small Big Thing #MMPMID26861301 Kalra H; Drummen GPC; Mathivanan S Int J Mol Sci 2016[Feb]; 17 (2): ä PMID26861301show ga Intercellular communication was long thought to be regulated exclusively through direct contact between cells or via release of soluble molecules that transmit the signal by binding to a suitable receptor on the target cell, and/or via uptake into that cell. With the discovery of small secreted vesicular structures that contain complex cargo, both in their lumen and the lipid membrane that surrounds them, a new frontier of signal transduction was discovered. These ?extracellular vesicles? (EV) were initially thought to be garbage bags through which the cell ejected its waste. Whilst this is a major function of one type of EV, i.e., apoptotic bodies, many EVs have intricate functions in intercellular communication and compound exchange; although their physiological roles are still ill-defined. Additionally, it is now becoming increasingly clear that EVs mediate disease progression and therefore studying EVs has ignited significant interests among researchers from various fields of life sciences. Consequently, the research effort into the pathogenic roles of EVs is significantly higher even though their protective roles are not well established. The ?Focus on extracellular vesicles? series of reviews highlights the current state of the art regarding various topics in EV research, whilst this review serves as an introductory overview of EVs, their biogenesis and molecular composition. äFocus on Extracellular Vesicles: Introducing the Next Small Big Thing (epmc).pdf DeepDyve Pubget Overpricing