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10.3390/ijms17020144 http://scihub22266oqcxt.onion/10.3390/ijms17020144 C4783878!4783878!26821017     free     free     free Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 215.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Int+J+Mol+Sci 2016 ; 17 (2): ä Nephropedia Template TP {{tp|p=26821017|t=2016. Insights into Protein?Ligand Interactions: Mechanisms, Models, and Methods |pdf=|usr=}}{{26821017}} gab.com Text Insights into Protein Ligand Interactions: Mechanisms, Models, and Methods JO: Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26821017 #FOAvip Molecular recognition, which is the process of biological macromolecules interacting with each other or various small molecules with a high specificity and affinity to form a specific complex, constitutes the basis of all processes in living organisms. Proteins, an important class of biological macromolecules, realize their functions through binding to themselves or other molecules. A detailed understanding of the protein?ligand interactions is therefore central to understanding biology at the molecular level. Moreover, knowledge of the mechanisms responsible for the protein-ligand recognition and binding will also facilitate the discovery, design, and development of drugs. In the present review, first, the physicochemical mechanisms underlying protein?ligand binding, including the binding kinetics, thermodynamic concepts and relationships, and binding driving forces, are introduced and rationalized. Next, three currently existing protein-ligand binding models?the ?lock-and-key?, ?induced fit?, and ?conformational selection??are described and their underlying thermodynamic mechanisms are discussed. Finally, the methods available for investigating protein?ligand binding affinity, including experimental and theoretical/computational approaches, are introduced, and their advantages, disadvantages, and challenges are discussed. Twit Text FOAVip Insights into Protein Ligand Interactions: Mechanisms, Models, and Methods ????Int J Mol Sci http://www.kidney.de/pget.php?&tw=1&pmid=26821017 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26821017 #FOAvip English Wikipedia <ref>{{Cite pmid|26821017}}</ref> Insights into Protein?Ligand Interactions: Mechanisms, Models, and Methods #MMPMID26821017 Du X; Li Y; Xia YL; Ai SM; Liang J; Sang P; Ji XL; Liu SQ Int J Mol Sci 2016[Feb]; 17 (2): ä PMID26821017show ga Molecular recognition, which is the process of biological macromolecules interacting with each other or various small molecules with a high specificity and affinity to form a specific complex, constitutes the basis of all processes in living organisms. Proteins, an important class of biological macromolecules, realize their functions through binding to themselves or other molecules. A detailed understanding of the protein?ligand interactions is therefore central to understanding biology at the molecular level. Moreover, knowledge of the mechanisms responsible for the protein-ligand recognition and binding will also facilitate the discovery, design, and development of drugs. In the present review, first, the physicochemical mechanisms underlying protein?ligand binding, including the binding kinetics, thermodynamic concepts and relationships, and binding driving forces, are introduced and rationalized. Next, three currently existing protein-ligand binding models?the ?lock-and-key?, ?induced fit?, and ?conformational selection??are described and their underlying thermodynamic mechanisms are discussed. Finally, the methods available for investigating protein?ligand binding affinity, including experimental and theoretical/computational approaches, are introduced, and their advantages, disadvantages, and challenges are discussed. äInsights into Protein?Ligand Interactions: Mechanisms, Models, and Met(epmc).pdf DeepDyve Pubget Overpricing