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10.1038/nm.3073 http://scihub22266oqcxt.onion/10.1038/nm.3073 C4783790!4783790!23389616     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Med 2013 ; 19 (2): 156-67 Nephropedia Template TP {{tp|p=23389616|t=2013. Malaria biology and disease pathogenesis: insights for new treatments |pdf=|usr=}}{{23389616}} gab.com Text Malaria biology and disease pathogenesis: insights for new treatments JO: Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=23389616 #FOAvip Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan, claims the lives of nearly a million children each year in Africa alone and is a top public health concern. Evidence is accumulating that resistance to artemisinin derivatives, the frontline therapy for the asexual blood stage of the infection, is developing in southeast Asia. Renewed initiatives to eliminate malaria will benefit from an expanded repertoire of antimalarials, including new drugs that kill circulating P. falciparum gametocytes, thereby preventing transmission. Our current understanding of the biology of asexual blood-stage parasites and gametocytes and the ability to culture them in vitro lends optimism that high-throughput screenings of large chemical libraries will produce a new generation of antimalarial drugs. There is also a need for new therapies to reduce the high mortality of severe malaria. An understanding of the pathophysiology of severe disease may identify rational targets for drugs that improve survival. Twit Text FOAVip Malaria biology and disease pathogenesis: insights for new treatments ????Nat Med http://www.kidney.de/pget.php?&tw=1&pmid=23389616 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23389616 #FOAvip English Wikipedia <ref>{{Cite pmid|23389616}}</ref> Malaria biology and disease pathogenesis: insights for new treatments #MMPMID23389616 Miller LH; Ackerman HC; Su Xz; Wellems TE Nat Med 2013[Feb]; 19 (2): 156-67 PMID23389616show ga Plasmodium falciparum malaria, an infectious disease caused by a parasitic protozoan, claims the lives of nearly a million children each year in Africa alone and is a top public health concern. Evidence is accumulating that resistance to artemisinin derivatives, the frontline therapy for the asexual blood stage of the infection, is developing in southeast Asia. Renewed initiatives to eliminate malaria will benefit from an expanded repertoire of antimalarials, including new drugs that kill circulating P. falciparum gametocytes, thereby preventing transmission. Our current understanding of the biology of asexual blood-stage parasites and gametocytes and the ability to culture them in vitro lends optimism that high-throughput screenings of large chemical libraries will produce a new generation of antimalarial drugs. There is also a need for new therapies to reduce the high mortality of severe malaria. An understanding of the pathophysiology of severe disease may identify rational targets for drugs that improve survival. äMalaria biology and disease pathogenesis: insights for new treatments (epmc).pdf DeepDyve Pubget Overpricing