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Lung ventilation strategies for acute respiratory distress syndrome: a systematic review and network meta-analysis #MMPMID26955891
Wang C; Wang X; Chi C; Guo L; Guo L; Zhao N; Wang W; Pi X; Sun B; Lian A; Shi J; Li E
Sci Rep 2016[]; 6 (ä): ä PMID26955891show ga
To identify the best lung ventilation strategy for acute respiratory distress syndrome (ARDS), we performed a network meta-analysis. The Cochrane Central Register of Controlled Trials, EMBASE, MEDLINE, CINAHL, and the Web of Science were searched, and 36 eligible articles were included. Compared with higher tidal volumes with FiO2-guided lower positive end-expiratory pressure [PEEP], the hazard ratios (HRs) for mortality were 0.624 (95% confidence interval (CI) 0.419?0.98) for lower tidal volumes with FiO2-guided lower PEEP and prone positioning and 0.572 (0.34?0.968) for pressure-controlled ventilation with FiO2-guided lower PEEP. Lower tidal volumes with FiO2-guided higher PEEP and prone positioning had the greatest potential to reduce mortality, and the possibility of receiving the first ranking was 61.6%. Permissive hypercapnia, recruitment maneuver, and low airway pressures were most likely to be the worst in terms of all-cause mortality. Compared with higher tidal volumes with FiO2-guided lower PEEP, pressure-controlled ventilation with FiO2-guided lower PEEP and lower tidal volumes with FiO2-guided lower PEEP and prone positioning ventilation are associated with lower mortality in ARDS patients. Lower tidal volumes with FiO2-guided higher PEEP and prone positioning ventilation and lower tidal volumes with pressure-volume (P?V) static curve-guided individual PEEP are potential optimal strategies for ARDS patients.