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10.1038/srep22844

http://scihub22266oqcxt.onion/10.1038/srep22844
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C4783788!4783788!26957350
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suck abstract from ncbi


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pmid26957350      Sci+Rep 2016 ; 6 (ä): ä
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  • Immune Infertility Should Be Positively Diagnosed Using an Accurate Method by Monitoring the Level of Anti-ACTL7a Antibody #MMPMID26957350
  • Fu J; Yao R; Luo Y; Yang D; Cao Y; Qiu Y; Song W; Miao S; Gu Y; Wang L
  • Sci Rep 2016[]; 6 (ä): ä PMID26957350show ga
  • Infertility is currently a major public health problem. Anti-sperm antibodies (ASAs) markedly reduce sperm quality, which can subsequently lead to male and/or female infertility. The accurate detection of ASAs derived from specific spermatozoa is, therefore, clinically useful. We have focused on the spermatozoa-specific expression protein ACTL7a for many years and have developed an enzyme-linked immunosorbent assay (ELISA) to detect the concentration of anti-ACTL7a antibodies in fertile sera (n?=?267) and infertile sera (n?=?193). Infertile sera were collected from the positive sera of tray agglutination tests (TAT), which is a routine ASA screening methodology. We found that the concentration of anti-ACTL7a antibodies was significantly higher in the infertile sera (than in the fertile sera, P?
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