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10.1038/cr.2016.11 http://scihub22266oqcxt.onion/10.1038/cr.2016.11 C4783464!4783464!26794869     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Res 2016 ; 26 (3): 367-79 Nephropedia Template TP {{tp|p=26794869|t=2016. The kinase activity of PKR represses inflammasome activity |pdf=|usr=}}{{26794869}} gab.com Text The kinase activity of PKR represses inflammasome activity JO: Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=26794869 #FOAvip The protein kinase R (PKR) functions in the antiviral response by controlling protein translation and inflammatory cell signaling pathways. We generated a transgenic, knock-in mouse in which the endogenous PKR is expressed with a point mutation that ablates its kinase activity. This novel animal allows us to probe the kinase-dependent and -independent functions of PKR. We used this animal together with a previously generated transgenic mouse that is ablated for PKR expression to determine the role of PKR in regulating the activity of the cryopyrin inflammasome. Our data demonstrate that, in contradiction to earlier reports, PKR represses cryopyrin inflammasome activity. We demonstrate that this control is mediated through the established function of PKR to inhibit protein translation of constituents of the inflammasome to prevent initial priming during innate immune signaling. These findings identify an important role for PKR to dampen inflammation during the innate immune response and caution against the previously proposed therapeutic strategy to inhibit PKR to treat inflammation. Twit Text FOAVip The kinase activity of PKR represses inflammasome activity ????Cell Res http://www.kidney.de/pget.php?&tw=1&pmid=26794869 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26794869 #FOAvip English Wikipedia <ref>{{Cite pmid|26794869}}</ref> The kinase activity of PKR represses inflammasome activity #MMPMID26794869 Yim HC; Wang D; Yu L; White CL; Faber PW; Williams BR; Sadler AJ Cell Res 2016[Mar]; 26 (3): 367-79 PMID26794869show ga The protein kinase R (PKR) functions in the antiviral response by controlling protein translation and inflammatory cell signaling pathways. We generated a transgenic, knock-in mouse in which the endogenous PKR is expressed with a point mutation that ablates its kinase activity. This novel animal allows us to probe the kinase-dependent and -independent functions of PKR. We used this animal together with a previously generated transgenic mouse that is ablated for PKR expression to determine the role of PKR in regulating the activity of the cryopyrin inflammasome. Our data demonstrate that, in contradiction to earlier reports, PKR represses cryopyrin inflammasome activity. We demonstrate that this control is mediated through the established function of PKR to inhibit protein translation of constituents of the inflammasome to prevent initial priming during innate immune signaling. These findings identify an important role for PKR to dampen inflammation during the innate immune response and caution against the previously proposed therapeutic strategy to inhibit PKR to treat inflammation. äThe kinase activity of PKR represses inflammasome activity (epmc).pdf DeepDyve Pubget Overpricing