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10.3389/fonc.2016.00053 http://scihub22266oqcxt.onion/10.3389/fonc.2016.00053 C4783435!4783435!27014628     free     free     free       Front+Oncol 2016 ; 6 (ä): ä Nephropedia Template TP {{tp|p=27014628|t=2016. DUBs, New Members in the Hypoxia Signaling clUb |pdf=|usr=}}{{27014628}} gab.com Text DUBs, New Members in the Hypoxia Signaling clUb JO: Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27014628 #FOAvip Cellular protein homeostasis is tightly regulated by ubiquitination. Responsible for target protein ubiquitination is a class of enzymes, the so-called ubiquitin E3 ligases. They are opposed to a second class of enzymes, called deubiquitinating enzymes (DUBs), which can remove polyubiquitin chains from their specific target proteins. The coaction of the two sets of enzymes allows the cell to adapt its overall protein content and the abundance of particular proteins to a variety of cellular and environmental stresses, including hypoxia. In recent years, DUBs have been highlighted to play major roles in many diseases, including cancer, both as tumor suppressors and oncogenes. Therefore, DUBs are emerging as promising targets for cancer-cell specific treatment. Here, we will review the current understanding of DUBs implicated in the control of hypoxia-inducible factor, the regulation of DUBs by hypoxia, and the use of DUB-specific drugs to target tumor hypoxia-signaling. Twit Text FOAVip DUBs, New Members in the Hypoxia Signaling clUb ????Front Oncol http://www.kidney.de/pget.php?&tw=1&pmid=27014628 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27014628 #FOAvip English Wikipedia <ref>{{Cite pmid|27014628}}</ref> DUBs, New Members in the Hypoxia Signaling clUb #MMPMID27014628 Schober AS; Berra E Front Oncol 2016[]; 6 (ä): ä PMID27014628show ga Cellular protein homeostasis is tightly regulated by ubiquitination. Responsible for target protein ubiquitination is a class of enzymes, the so-called ubiquitin E3 ligases. They are opposed to a second class of enzymes, called deubiquitinating enzymes (DUBs), which can remove polyubiquitin chains from their specific target proteins. The coaction of the two sets of enzymes allows the cell to adapt its overall protein content and the abundance of particular proteins to a variety of cellular and environmental stresses, including hypoxia. In recent years, DUBs have been highlighted to play major roles in many diseases, including cancer, both as tumor suppressors and oncogenes. Therefore, DUBs are emerging as promising targets for cancer-cell specific treatment. Here, we will review the current understanding of DUBs implicated in the control of hypoxia-inducible factor, the regulation of DUBs by hypoxia, and the use of DUB-specific drugs to target tumor hypoxia-signaling. äDUBs, New Members in the Hypoxia Signaling clUb (epmc).pdf DeepDyve Pubget Overpricing