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10.1007/s13365-015-0378-3 http://scihub22266oqcxt.onion/10.1007/s13365-015-0378-3 C4783292!4783292!26419894     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Neurovirol 2016 ; 22 (2): 140-8 Nephropedia Template TP {{tp|p=26419894|t=2016. Neuropathogenesis of Chikungunya Infection: Astrogliosis and Innate Immune Activation |pdf=|usr=}}{{26419894}} gab.com Text Neuropathogenesis of Chikungunya Infection: Astrogliosis and Innate Immune Activation JO: J Neurovirol http://www.kidney.de/pget.php?&tw=1&pmid=26419894 #FOAvip Chikungunya, ?that which bends up? in the Makonde dialect, is an emerging global health threat, with increasing incidence of neurological complications. Until 2013, Chikungunya infection had been largely restricted to East Africa and the Indian Ocean, with cases within the US reported to be from foreign travel. However, in 2014, over 1 million suspected cases were reported in the Americas, and a recently infected human could serve as an unwitting reservoir for the virus resulting in an epidemic in the continental US. Chikungunya infection is increasingly being associated with neurological sequelae. In this study, we sought to understand the role of astrocytes in the neuropathogenesis of Chikungunya infection. Even after virus has been cleared form the circulation, astrocytes were activated with regards to TLR2 expression. In addition white matter astrocytes were hypertrophic, with increased arbor volume in gray matter astrocytes. Combined, these would alter the number and distribution of synapses that each astrocyte would be capable of forming. These results provide the first evidence that Chikungunya infection induces morphometric and innate immune activation of astrocytes in vivo. Perturbed glia-neuron signaling could be a major driving factor in the development of Chikungunya-associated neuropathology. Twit Text FOAVip Neuropathogenesis of Chikungunya Infection: Astrogliosis and Innate Immune Activation ????J Neurovirol http://www.kidney.de/pget.php?&tw=1&pmid=26419894 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26419894 #FOAvip English Wikipedia <ref>{{Cite pmid|26419894}}</ref> Neuropathogenesis of Chikungunya Infection: Astrogliosis and Innate Immune Activation #MMPMID26419894 Inglis FM; Lee KM; Chiu KB; Purcell OM; Didier PJ; Russell-Lodrigues K; Weaver SC; Roy CJ; MacLean AG J Neurovirol 2016[Apr]; 22 (2): 140-8 PMID26419894show ga Chikungunya, ?that which bends up? in the Makonde dialect, is an emerging global health threat, with increasing incidence of neurological complications. Until 2013, Chikungunya infection had been largely restricted to East Africa and the Indian Ocean, with cases within the US reported to be from foreign travel. However, in 2014, over 1 million suspected cases were reported in the Americas, and a recently infected human could serve as an unwitting reservoir for the virus resulting in an epidemic in the continental US. Chikungunya infection is increasingly being associated with neurological sequelae. In this study, we sought to understand the role of astrocytes in the neuropathogenesis of Chikungunya infection. Even after virus has been cleared form the circulation, astrocytes were activated with regards to TLR2 expression. In addition white matter astrocytes were hypertrophic, with increased arbor volume in gray matter astrocytes. Combined, these would alter the number and distribution of synapses that each astrocyte would be capable of forming. These results provide the first evidence that Chikungunya infection induces morphometric and innate immune activation of astrocytes in vivo. Perturbed glia-neuron signaling could be a major driving factor in the development of Chikungunya-associated neuropathology. äNeuropathogenesis of Chikungunya Infection: Astrogliosis and Innate Im(epmc).pdf DeepDyve Pubget Overpricing