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10.1016/j.tibs.2016.01.002 http://scihub22266oqcxt.onion/10.1016/j.tibs.2016.01.002 C4783264!4783264!26873641     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Biochem+Sci 2016 ; 41 (3): 219-30 Nephropedia Template TP {{tp|p=26873641|t=2016. Pyruvate and Metabolic Flexibility: Illuminating a path toward selective cancer therapies |pdf=|usr=}}{{26873641}} gab.com Text Pyruvate and Metabolic Flexibility: Illuminating a path toward selective cancer therapies JO: Trends Biochem Sci http://www.kidney.de/pget.php?&tw=1&pmid=26873641 #FOAvip Dysregulated metabolism is an emerging hallmark of cancer and there is abundant interest in developing therapies to selectively target these aberrant metabolic phenotypes. Sitting at the decision point between mitochondrial carbohydrate oxidation and aerobic glycolysis (i.e., the ?Warburg Effect?), the synthesis and consumption of pyruvate is tightly controlled and is often differentially regulated in cancer cells. This review examines recent efforts toward understanding and targeting mitochondrial pyruvate metabolism, and addresses some of the successes, pitfalls and significant challenges of metabolic therapy to date. Twit Text FOAVip Pyruvate and Metabolic Flexibility: Illuminating a path toward selective cancer therapies ????Trends Biochem Sci http://www.kidney.de/pget.php?&tw=1&pmid=26873641 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26873641 #FOAvip English Wikipedia <ref>{{Cite pmid|26873641}}</ref> Pyruvate and Metabolic Flexibility: Illuminating a path toward selective cancer therapies #MMPMID26873641 Olson KA; Schell JC; Rutter J Trends Biochem Sci 2016[Mar]; 41 (3): 219-30 PMID26873641show ga Dysregulated metabolism is an emerging hallmark of cancer and there is abundant interest in developing therapies to selectively target these aberrant metabolic phenotypes. Sitting at the decision point between mitochondrial carbohydrate oxidation and aerobic glycolysis (i.e., the ?Warburg Effect?), the synthesis and consumption of pyruvate is tightly controlled and is often differentially regulated in cancer cells. This review examines recent efforts toward understanding and targeting mitochondrial pyruvate metabolism, and addresses some of the successes, pitfalls and significant challenges of metabolic therapy to date. äPyruvate and Metabolic Flexibility: Illuminating a path toward selecti(epmc).pdf DeepDyve Pubget Overpricing