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MicroRNA deregulation in cancer cells and the tumor microenvironment #MMPMID26865249
Rupaimoole R; Calin GA; Lopez-Berestein G; Sood AK
Cancer Discov 2016[Mar]; 6 (3): 235-46 PMID26865249show ga
MicroRNAs (miRNAs) are a key component of the noncoding RNA family. The underlying mechanisms involved in the interplay between the tumor microenvironment and cancer cells involve highly dynamic factors such as hypoxia and cell types such as cancer-associated fibroblasts and macrophages. Although miRNA levels are known to be altered in cancer cells, recent evidence suggests a critical role for the tumor microenvironment in regulating miRNA biogenesis, methylation, and transcriptional changes. Here, we discuss the complex pro-tumorigenic symbiotic role between tumor cells, the tumor microenvironment, and miRNA deregulation.