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Mechanisms and Dynamics of Protein Acetylation in Mitochondria #MMPMID26822488
Baeza J; Smallegan MJ; Denu JM
Trends Biochem Sci 2016[Mar]; 41 (3): 231-44 PMID26822488show ga
Reversible protein acetylation is a major regulatory mechanism for controlling protein function. Through genetic manipulations, dietary perturbations, and new proteomic technologies, the diverse functions of protein acetylation are coming into focus. Protein acetylation in mitochondria has taken center stage, revealing that 63% of mitochondrially localized proteins contain lysine acetylation sites. Here we summarize the field, and discuss salient topics that cover spurious versus targeted acetylation, the role of SIRT3 deacetylation, nonenzymatic acetylation, and molecular models for regulatory acetylations that display high and low stoichiometry.