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Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Methods+Mol+Biol 2012 ; 802 (ä): 305-22 Nephropedia Template TP
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ChIP-Seq Data Analysis: Identification of Protein?DNA Binding Sites with SISSRs Peak-Finder #MMPMID22130889
Narlikar L; Jothi R
Methods Mol Biol 2012[]; 802 (ä): 305-22 PMID22130889show ga
Protein?DNA interactions play key roles in determining gene-expression programs during cellular development and differentiation. Chromatin immunoprecipitation (ChIP) is the most widely used assay for probing such interactions. With recent advances in sequencing technology, ChIP-Seq, an approach that combines ChIP and next-generation parallel sequencing is fast becoming the method of choice for mapping protein?DNA interactions on a genome-wide scale. Here, we briefly review the ChIP-Seq approach for mapping protein?DNA interactions and describe the use of the SISSRs peak-finder, a software tool for precise identification of protein?DNA binding sites from sequencing data generated using ChIP-Seq.