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10.1053/j.gastro.2008.10.031 http://scihub22266oqcxt.onion/10.1053/j.gastro.2008.10.031 C4782934!4782934 !19032955     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19032955 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Gastroenterology 2009 ; 136 (2 ): 630-9 Nephropedia Template TP {{tp|p=19032955 |t=2009. Changes in the structure and function of ICC networks in ICC hyperplasia and gastrointestinal stromal tumors |pdf=|usr=}}{{19032955 }} gab.com Text Changes in the structure and function of ICC networks in ICC hyperplasia and gastrointestinal stromal tumors JO: Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=19032955 #FOAvip BACKGROUND & AIMS: Gastrointestinal stromal tumors (GISTs) express the receptor tyrosine kinase c-kit. Approximately 90% of GISTs have gain-of-function mutations in the Kit gene, which leads to its constitutive activation and drives malignant behavior of GISTs. Interstitial cells of Cajal (ICC) express c-kit; however, it is unknown whether uncontrolled hyperplasia of ICC is responsible for GISTs. Here, we sought to determine whether gain-of-function mutations in Kit lead to hyperplasia of all classes of ICC, whether ICC hyperplasia begins before birth, and whether functional defects occur in ICC hyperplasia or the development of GISTs. METHODS: Heterozygous mutant Kit(V558Delta)/+ mice that develop symptoms of human familial GISTs and prematurely die from pathology of the gastrointestinal tract were utilized and compared with wild-type controls. C-kit-immunohistochemistry and intracellular electrical recording of spontaneous and nerve-evoked activity were applied to examine the density and functionality of ICC in these mutants. RESULTS: There was considerable hyperplasia in all classes of ICC throughout the GI tract of Kit(V558Delta)/+ mice, except for ICC in the deep muscular plexus of the intestine. Spontaneous electrical activity and postjunctional neural responses in hyperplastic ICC tissues appeared normal but were up-regulated in the cecum, where GISTs were commonly found. CONCLUSIONS: Kit gain-of-function leads to hyperplasia of most classes of ICC throughout the GI tract. ICC retain normal pacemaker function and enteric neural responses well after development of hyperplasia. Twit Text FOAVip Changes in the structure and function of ICC networks in ICC hyperplasia and gastrointestinal stromal tumors ????Gastroenterology http://www.kidney.de/pget.php?&tw=1&pmid=19032955 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19032955 #FOAvip English Wikipedia <ref>{{Cite pmid|19032955 }}</ref> Changes in the structure and function of ICC networks in ICC hyperplasia and gastrointestinal stromal tumors #MMPMID19032955 Kwon JG ; Hwang SJ ; Hennig GW ; Bayguinov Y ; McCann C ; Chen H ; Rossi F ; Besmer P ; Sanders KM ; Ward SM Gastroenterology 2009[Feb]; 136 (2 ): 630-9 PMID19032955 show ga BACKGROUND & AIMS: Gastrointestinal stromal tumors (GISTs) express the receptor tyrosine kinase c-kit. Approximately 90% of GISTs have gain-of-function mutations in the Kit gene, which leads to its constitutive activation and drives malignant behavior of GISTs. Interstitial cells of Cajal (ICC) express c-kit; however, it is unknown whether uncontrolled hyperplasia of ICC is responsible for GISTs. Here, we sought to determine whether gain-of-function mutations in Kit lead to hyperplasia of all classes of ICC, whether ICC hyperplasia begins before birth, and whether functional defects occur in ICC hyperplasia or the development of GISTs. METHODS: Heterozygous mutant Kit(V558Delta)/+ mice that develop symptoms of human familial GISTs and prematurely die from pathology of the gastrointestinal tract were utilized and compared with wild-type controls. C-kit-immunohistochemistry and intracellular electrical recording of spontaneous and nerve-evoked activity were applied to examine the density and functionality of ICC in these mutants. RESULTS: There was considerable hyperplasia in all classes of ICC throughout the GI tract of Kit(V558Delta)/+ mice, except for ICC in the deep muscular plexus of the intestine. Spontaneous electrical activity and postjunctional neural responses in hyperplastic ICC tissues appeared normal but were up-regulated in the cecum, where GISTs were commonly found. CONCLUSIONS: Kit gain-of-function leads to hyperplasia of most classes of ICC throughout the GI tract. ICC retain normal pacemaker function and enteric neural responses well after development of hyperplasia. |Animals [MESH] |Cecum/metabolism/pathology/physiopathology [MESH] |Colon/metabolism/pathology/physiopathology [MESH] |Disease Models, Animal [MESH] |Electrophysiological Phenomena [MESH] |Enteric Nervous System/physiopathology [MESH] |Fetus/metabolism/pathology/physiopathology [MESH] |Gastric Fundus/metabolism/pathology/physiopathology [MESH] |Gastrointestinal Stromal Tumors/metabolism/*pathology/*physiopathology [MESH] |Gastrointestinal Tract/metabolism/*pathology/*physiopathology [MESH] |Hyperplasia/metabolism/pathology/physiopathology [MESH] |Ileum/metabolism/pathology/physiopathology [MESH] |Jejunum/metabolism/pathology/physiopathology [MESH] |Male [MESH] |Mice [MESH] |Mice, Mutant Strains [MESH] |Muscle, Smooth/metabolism/*pathology/*physiopathology [MESH] |Proto-Oncogene Proteins c-kit/genetics/metabolism [MESH]Changes in the structure and function of ICC networks in ICC hyperplas(epmc).pdf DeepDyve Pubget Overpricing