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10.1097/MD.0000000000002921 http://scihub22266oqcxt.onion/10.1097/MD.0000000000002921 C4782878!4782878!26945394     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Medicine+(Baltimore) 2016 ; 95 (9): ä Nephropedia Template TP {{tp|p=26945394|t=2016. Serum Hepcidin Levels in Childhood-Onset Ischemic Stroke: A Case-Control Study |pdf=|usr=}}{{26945394}} gab.com Text Serum Hepcidin Levels in Childhood-Onset Ischemic Stroke: A Case-Control Study JO: Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=26945394 #FOAvip Recently, hepcidin, an antimicrobial-like peptide hormone, has evolved as the master regulator of iron homeostasis. Despite the growing evidence of iron imbalance in childhood-onset ischemic stroke, serum hepcidin level in those patients has not yet been researched.In this study, we aimed to estimate serum (hepcidin) level in acute ischemic stroke (AIS) patients and to investigate whether subcutaneous enoxaparin sodium, which is a low-molecular-weight heparin (LMWH) derivative, could modulate serum hepcidin level in those patients.This was a case?control study included 60 (AIS) cases, and 100 healthy children with comparable age and gender as control group. For all subjects? serum hepcidin, interleukin-6 (IL-6), and soluble transferrin receptor [sTfR]) levels were assessed by (enzyme-linked immunosorbent assay [ELISA] method). Iron parameters including (serum iron, ferritin, transferrin, and total iron binding capacity [TIBC]) were also measured. The patients were subdivided according to treatment with an LMWH derivative into 2 groups and serum hepcidin levels were assessed initially and 1 week after stroke onset for all cases.We found that AIS cases had higher serum iron, ferritin, and IL6 levels compared to the control group (all P?<?0.01). Serum hepcidin was significantly higher in AIS cases (median, 36[15?73]ng/mL) compared to the control group (median, 24[10?41]ng/mL; P?<?0.01). On the 1st day of AIS diagnosis, serum hepcidin levels were similar in both stroke subgroups (P?>?0.05). However, on the 7th day of diagnosis serum hepcidin level decreased significantly in AIS cases treated with LMWH (group 1) (median, 36 vs 21?ng/mL; P?<?0.01, respectively). Meanwhile, no significant change was observed in serum hepcidin level in AIS cases not treated with LMWH (group 2) (P?>?0.05). Serum hepcidin showed significant positive correlations with serum iron, transferrin saturation, ferritin, and IL6 (r?=?0.375, P?<?0.05; r?=?0.453, P?<?0.05; r?=?0.687, P?<?0.01; r?=?0.515, P?<?0.01; respectively).Our data brought a novel observation of elevated serum hepcidin level in pediatric AIS patients and pointed out that treatment with LMWH could modulate hepcidin level in those patients. Twit Text FOAVip Serum Hepcidin Levels in Childhood-Onset Ischemic Stroke: A Case-Control Study ????Medicine (Baltimore) http://www.kidney.de/pget.php?&tw=1&pmid=26945394 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26945394 #FOAvip English Wikipedia <ref>{{Cite pmid|26945394}}</ref> Serum Hepcidin Levels in Childhood-Onset Ischemic Stroke: A Case-Control Study #MMPMID26945394 Azab SF; Akeel NE; Abdalhady MA; Elhewala AA; Ali ASA; Amin EK; Sarhan DT; Almalky MA; Elhindawy EM; Salam MM; Soliman AA; Abdellatif SH; Ismail SM; Elsamad NA; Hashem MI; Aziz KA; Elazouni OM; Arafat MS Medicine (Baltimore) 2016[Mar]; 95 (9): ä PMID26945394show ga Recently, hepcidin, an antimicrobial-like peptide hormone, has evolved as the master regulator of iron homeostasis. Despite the growing evidence of iron imbalance in childhood-onset ischemic stroke, serum hepcidin level in those patients has not yet been researched.In this study, we aimed to estimate serum (hepcidin) level in acute ischemic stroke (AIS) patients and to investigate whether subcutaneous enoxaparin sodium, which is a low-molecular-weight heparin (LMWH) derivative, could modulate serum hepcidin level in those patients.This was a case?control study included 60 (AIS) cases, and 100 healthy children with comparable age and gender as control group. For all subjects? serum hepcidin, interleukin-6 (IL-6), and soluble transferrin receptor [sTfR]) levels were assessed by (enzyme-linked immunosorbent assay [ELISA] method). Iron parameters including (serum iron, ferritin, transferrin, and total iron binding capacity [TIBC]) were also measured. The patients were subdivided according to treatment with an LMWH derivative into 2 groups and serum hepcidin levels were assessed initially and 1 week after stroke onset for all cases.We found that AIS cases had higher serum iron, ferritin, and IL6 levels compared to the control group (all P??0.05). However, on the 7th day of diagnosis serum hepcidin level decreased significantly in AIS cases treated with LMWH (group 1) (median, 36 vs 21?ng/mL; P??0.05). Serum hepcidin showed significant positive correlations with serum iron, transferrin saturation, ferritin, and IL6 (r?=?0.375, P? äSerum Hepcidin Levels in Childhood-Onset Ischemic Stroke: A Case-Contr(epmc).pdf DeepDyve Pubget Overpricing