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10.1093/bmb/ldv057

http://scihub22266oqcxt.onion/10.1093/bmb/ldv057
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C4782751!4782751!26872857
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suck abstract from ncbi


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pmid26872857      Br+Med+Bull 2016 ; 117 (1): 139-48
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  • The aetiopathogenesis of fatigue: unpredictable, complex and persistent #MMPMID26872857
  • Clark JE; Fai Ng W; Watson S; Newton JL
  • Br Med Bull 2016[Mar]; 117 (1): 139-48 PMID26872857show ga
  • Background: Chronic fatigue syndrome is a common condition characterized by severe fatigue with post-exertional malaise, impaired cognitive ability, poor sleep quality, muscle pain, multi-joint pain, tender lymph nodes, sore throat or headache. Its defining symptom, fatigue is common to several diseases. Areas of agreement: Research has established a broad picture of impairment across autonomic, endocrine and inflammatory systems though progress seems to have reached an impasse. Areas of controversy: The absence of a clear consensus view of the pathophysiology of fatigue suggests the need to switch from a focus on abnormalities in one system to an experimental and clinical approach which integrates findings across multiple systems and their constituent parts and to consider multiple environmental factors. Growing points: We discuss this with reference to three key factors, non-determinism, non-reductionism and self-organization and suggest that an approach based on these principles may afford a coherent explanatory framework for much of the observed phenomena in fatigue and offers promising avenues for future research. Areas timely for developing research: By adopting this approach, the field can examine issues regarding aetiopathogenesis and treatment, with relevance for future research and clinical practice.
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