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10.1002/mds.23251 http://scihub22266oqcxt.onion/10.1002/mds.23251 C4782591!4782591!20669182     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Mov+Disord 2010 ; 25 (13): 2148-55 Nephropedia Template TP {{tp|p=20669182|t=2010. Characteristics of the Sequence Effect in Parkinson?s Disease |pdf=|usr=}}{{20669182}} gab.com Text Characteristics of the Sequence Effect in Parkinson s Disease JO: Mov Disord http://www.kidney.de/pget.php?&tw=1&pmid=20669182 #FOAvip The sequence effect (SE) in Parkinson?s disease (PD) is progressive slowing of sequential movements. It is a feature of bradykinesia, but is separate from a general slowness without deterioration over time. It is commonly seen in PD, but its physiology is unclear. We measured general slowness and the SE separately with a computer-based, modified Purdue pegboard in 11 patients with advanced PD. We conducted a placebo-controlled, four-way crossover study to learn whether levodopa and repetitive transcranial magnetic stimulation (rTMS) could improve general slowness or the SE. We also examined the correlation between the SE and clinical fatigue. Levodopa alone and rTMS alone improved general slowness, but rTMS showed no additive effect on levodopa. Levodopa alone, rTMS alone, and their combination did not alleviate the SE. There was no correlation between the SE and fatigue. This study suggests that dopaminergic dysfunction and abnormal motor cortex excitability are not the relevant mechanisms for the SE. Additionally, the SE is not a component of clinical fatigue. Further work is needed to establish the physiology and clinical relevance of the SE. Twit Text FOAVip Characteristics of the Sequence Effect in Parkinson s Disease ????Mov Disord http://www.kidney.de/pget.php?&tw=1&pmid=20669182 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20669182 #FOAvip English Wikipedia <ref>{{Cite pmid|20669182}}</ref> Characteristics of the Sequence Effect in Parkinson?s Disease #MMPMID20669182 Kang SY; Wasaka T; Shamim EA; Auh S; Ueki Y; Lopez GJ; Kida T; Jin SH; Dang N; Hallett M Mov Disord 2010[Oct]; 25 (13): 2148-55 PMID20669182show ga The sequence effect (SE) in Parkinson?s disease (PD) is progressive slowing of sequential movements. It is a feature of bradykinesia, but is separate from a general slowness without deterioration over time. It is commonly seen in PD, but its physiology is unclear. We measured general slowness and the SE separately with a computer-based, modified Purdue pegboard in 11 patients with advanced PD. We conducted a placebo-controlled, four-way crossover study to learn whether levodopa and repetitive transcranial magnetic stimulation (rTMS) could improve general slowness or the SE. We also examined the correlation between the SE and clinical fatigue. Levodopa alone and rTMS alone improved general slowness, but rTMS showed no additive effect on levodopa. Levodopa alone, rTMS alone, and their combination did not alleviate the SE. There was no correlation between the SE and fatigue. This study suggests that dopaminergic dysfunction and abnormal motor cortex excitability are not the relevant mechanisms for the SE. Additionally, the SE is not a component of clinical fatigue. Further work is needed to establish the physiology and clinical relevance of the SE. äCharacteristics of the Sequence Effect in Parkinson?s Disease (epmc).pdf DeepDyve Pubget Overpricing