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10.1186/s12974-016-0523-9 http://scihub22266oqcxt.onion/10.1186/s12974-016-0523-9 C4782566!4782566 !26952098     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26952098 &cmd=llinks): Failed to open stream: HTTP request failed! 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Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke |pdf=|usr=}}{{26952098 }} gab.com Text Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke JO: J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=26952098 #FOAvip BACKGROUND: Microglia are the resident macrophage population of the central nervous system (CNS) and play essential roles, particularly in inflammation-mediated pathological conditions such as ischemic stroke. Increasing evidence shows that the population of vascular cells located around the blood vessels, rather than circulating cells, harbor stem cells and that these resident vascular stem cells (VSCs) are the likely source of some microglia. However, the precise traits and origins of these cells under pathological CNS conditions remain unclear. METHODS: In this study, we used a mouse model of cerebral infarction to investigate whether reactive pericytes (PCs) acquire microglia-producing VSC activity following ischemia. RESULTS: We demonstrated the localization of ionized calcium-binding adaptor molecule 1 (Iba1)-expressing microglia to perivascular regions within ischemic areas. These cells expressed platelet-derived growth factor receptor-? (PDGFR?), a hallmark of vascular PCs. PDGFR?(+) PCs isolated from ischemic, but not non-ischemic, areas expressed stem/undifferentiated cell markers and subsequently differentiated into various cell types, including microglia-like cells with phagocytic capacity. CONCLUSIONS: The study results suggest that vascular PCs acquire multipotent VSC activity under pathological conditions and may thus be a novel source of microglia. Twit Text FOAVip Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke ????J Neuroinflammation http://www.kidney.de/pget.php?&tw=1&pmid=26952098 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26952098 #FOAvip English Wikipedia <ref>{{Cite pmid|26952098 }}</ref> Brain pericytes serve as microglia-generating multipotent vascular stem cells following ischemic stroke #MMPMID26952098 Sakuma R ; Kawahara M ; Nakano-Doi A ; Takahashi A ; Tanaka Y ; Narita A ; Kuwahara-Otani S ; Hayakawa T ; Yagi H ; Matsuyama T ; Nakagomi T J Neuroinflammation 2016[Mar]; 13 (1 ): 57 PMID26952098 show ga BACKGROUND: Microglia are the resident macrophage population of the central nervous system (CNS) and play essential roles, particularly in inflammation-mediated pathological conditions such as ischemic stroke. Increasing evidence shows that the population of vascular cells located around the blood vessels, rather than circulating cells, harbor stem cells and that these resident vascular stem cells (VSCs) are the likely source of some microglia. However, the precise traits and origins of these cells under pathological CNS conditions remain unclear. METHODS: In this study, we used a mouse model of cerebral infarction to investigate whether reactive pericytes (PCs) acquire microglia-producing VSC activity following ischemia. RESULTS: We demonstrated the localization of ionized calcium-binding adaptor molecule 1 (Iba1)-expressing microglia to perivascular regions within ischemic areas. These cells expressed platelet-derived growth factor receptor-? (PDGFR?), a hallmark of vascular PCs. PDGFR?(+) PCs isolated from ischemic, but not non-ischemic, areas expressed stem/undifferentiated cell markers and subsequently differentiated into various cell types, including microglia-like cells with phagocytic capacity. CONCLUSIONS: The study results suggest that vascular PCs acquire multipotent VSC activity under pathological conditions and may thus be a novel source of microglia. |Animals [MESH] |Brain Ischemia/metabolism/*pathology [MESH] |Brain/*pathology [MESH] |Cerebral Infarction/pathology [MESH] |Male [MESH] |Mice [MESH] |Microglia/metabolism/*pathology [MESH] |Pericytes/metabolism/*pathology [MESH] |Phagocytosis [MESH] |Receptor, Platelet-Derived Growth Factor beta/metabolism [MESH] |Stem Cells/metabolism/*pathology [MESH]Brain pericytes serve as microglia-generating multipotent vascular ste(epmc).pdf DeepDyve Pubget Overpricing