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10.1186/s12859-016-0961-5

http://scihub22266oqcxt.onion/10.1186/s12859-016-0961-5
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C4782413!4782413!26951498
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suck abstract from ncbi


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pmid26951498      BMC+Bioinformatics 2016 ; 17 (ä): ä
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  • Testing for association between RNA-Seq and high-dimensional data #MMPMID26951498
  • Rauschenberger A; Jonker MA; van de Wiel MA; Menezes RX
  • BMC Bioinformatics 2016[]; 17 (ä): ä PMID26951498show ga
  • Background: Testing for association between RNA-Seq and other genomic data is challenging due to high variability of the former and high dimensionality of the latter. Results: Using the negative binomial distribution and a random-effects model, we develop an omnibus test that overcomes both difficulties. It may be conceptualised as a test of overall significance in regression analysis, where the response variable is overdispersed and the number of explanatory variables exceeds the sample size. Conclusions: The proposed test can detect genetic and epigenetic alterations that affect gene expression. It can examine complex regulatory mechanisms of gene expression. The R package globalSeq is available from Bioconductor. Electronic supplementary material: The online version of this article (doi:10.1186/s12859-016-0961-5) contains supplementary material, which is available to authorized users.
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