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10.1186/s12931-016-0341-8 http://scihub22266oqcxt.onion/10.1186/s12931-016-0341-8 C4782295!4782295!26956558     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Respir+Res 2016 ; 17 (ä): ä Nephropedia Template TP {{tp|p=26956558|t=2016. Diet-induced obesity alters myeloid cell populations in naïve and injured lung |pdf=|usr=}}{{26956558}} gab.com Text Diet-induced obesity alters myeloid cell populations in naïve and injured lung JO: Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=26956558 #FOAvip Background: There are pulmonary consequences to obesity, including increased prevalence of asthma, greater susceptibility to influenza, and possibly reduced susceptibility to lung injury. Although it is well established that obesity is associated with alterations to the immune system, little is known about obesity-associated changes to pulmonary immune cells. Objectives: We hypothesized that obesity would alter the inflammatory milieu in the unchallenged lung and circulation; thereby contributing to altered susceptibility to lung injury. Methods: We used a murine model of diet-induced obesity and evaluated bone marrow and blood leukocytes at 3 months, and pulmonary leukocytes at 3 and 6 months for changes in their adhesion and chemokine receptors, markers of activation states, and cell numbers. We also evaluated the inflammatory response to LPS in obese mice. Results: In the lung, diet-induced obesity was associated with increased leukocyte numbers over-time. Adhesion receptors were increased in a cell- and site-specific fashion, and there was an evolution of macrophage and neutrophil polarization toward M1 and N1, respectively. After LPS-challenge, obesity was associated with increased neutrophil recruitment to the lung with impaired migration into the alveolar space. Associated with these changes, obesity increased LFA-1 and ICAM-1 neutrophil expression and altered CXCL1 gradients. Conclusion: Our results highlight the effects of diet-induced obesity on the murine blood and lung leukocyte populations, including increases in adhesion receptor expression that may contribute to altered recruitment or retention within the lung. Translation of these findings to people with obesity will be critical for determining the basic inflammatory underpinnings of pulmonary disease susceptibility. Electronic supplementary material: The online version of this article (doi:10.1186/s12931-016-0341-8) contains supplementary material, which is available to authorized users. Twit Text FOAVip Diet-induced obesity alters myeloid cell populations in naïve and injured lung ????Respir Res http://www.kidney.de/pget.php?&tw=1&pmid=26956558 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26956558 #FOAvip English Wikipedia <ref>{{Cite pmid|26956558}}</ref> Diet-induced obesity alters myeloid cell populations in naïve and injured lung #MMPMID26956558 Manicone AM; Gong K; Johnston LK; Giannandrea M Respir Res 2016[]; 17 (ä): ä PMID26956558show ga Background: There are pulmonary consequences to obesity, including increased prevalence of asthma, greater susceptibility to influenza, and possibly reduced susceptibility to lung injury. Although it is well established that obesity is associated with alterations to the immune system, little is known about obesity-associated changes to pulmonary immune cells. Objectives: We hypothesized that obesity would alter the inflammatory milieu in the unchallenged lung and circulation; thereby contributing to altered susceptibility to lung injury. Methods: We used a murine model of diet-induced obesity and evaluated bone marrow and blood leukocytes at 3 months, and pulmonary leukocytes at 3 and 6 months for changes in their adhesion and chemokine receptors, markers of activation states, and cell numbers. We also evaluated the inflammatory response to LPS in obese mice. Results: In the lung, diet-induced obesity was associated with increased leukocyte numbers over-time. Adhesion receptors were increased in a cell- and site-specific fashion, and there was an evolution of macrophage and neutrophil polarization toward M1 and N1, respectively. After LPS-challenge, obesity was associated with increased neutrophil recruitment to the lung with impaired migration into the alveolar space. Associated with these changes, obesity increased LFA-1 and ICAM-1 neutrophil expression and altered CXCL1 gradients. Conclusion: Our results highlight the effects of diet-induced obesity on the murine blood and lung leukocyte populations, including increases in adhesion receptor expression that may contribute to altered recruitment or retention within the lung. Translation of these findings to people with obesity will be critical for determining the basic inflammatory underpinnings of pulmonary disease susceptibility. Electronic supplementary material: The online version of this article (doi:10.1186/s12931-016-0341-8) contains supplementary material, which is available to authorized users. äDiet-induced obesity alters myeloid cell populations in naïve and inju(epmc).pdf DeepDyve Pubget Overpricing