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10.1038/nri2765 http://scihub22266oqcxt.onion/10.1038/nri2765 C4782221!4782221!20467426     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Rev+Immunol 2010 ; 10 (6): 387-402 Nephropedia Template TP {{tp|p=20467426|t=2010. The SYK tyrosine kinase: a crucial player in diverse biological functions |pdf=|usr=}}{{20467426}} gab.com Text The SYK tyrosine kinase: a crucial player in diverse biological functions JO: Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=20467426 #FOAvip Spleen tyrosine kinase (SYK) has been known to relay adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates novel targets including the CARD9/CARMA1?BCL10?MALT1 pathway and the NLRP3 inflammasome. Drosophila studies indicate evolutionary ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of SYK functions and the translation of this knowledge for therapeutic purposes. Twit Text FOAVip The SYK tyrosine kinase: a crucial player in diverse biological functions ????Nat Rev Immunol http://www.kidney.de/pget.php?&tw=1&pmid=20467426 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=20467426 #FOAvip English Wikipedia <ref>{{Cite pmid|20467426}}</ref> The SYK tyrosine kinase: a crucial player in diverse biological functions #MMPMID20467426 Mócsai A; Ruland J; Tybulewicz VLJ Nat Rev Immunol 2010[Jun]; 10 (6): 387-402 PMID20467426show ga Spleen tyrosine kinase (SYK) has been known to relay adaptive immune receptor signalling. However, recent reports indicate that SYK also mediates other, unexpectedly diverse biological functions including cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. SYK is activated by C-type lectins and integrins, and activates novel targets including the CARD9/CARMA1?BCL10?MALT1 pathway and the NLRP3 inflammasome. Drosophila studies indicate evolutionary ancient origin of SYK-mediated signalling. Moreover, SYK has a crucial role in autoimmune diseases and haematological malignancies. This Review summarizes our current understanding of SYK functions and the translation of this knowledge for therapeutic purposes. äThe SYK tyrosine kinase: a crucial player in diverse biological functi(epmc).pdf DeepDyve Pubget Overpricing