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10.1038/ncomms10844 http://scihub22266oqcxt.onion/10.1038/ncomms10844 C4782064!4782064!26936020     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Nat+Commun 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=26936020|t=2016. Elimination of HIV-1-infected cells by broadly neutralizing antibodies |pdf=|usr=}}{{26936020}} gab.com Text Elimination of HIV-1-infected cells by broadly neutralizing antibodies JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26936020 #FOAvip The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for suppressing viraemia, through mechanisms which remain poorly understood. Here, we identify bNAbs that exert antibody-dependent cellular cytotoxicity (ADCC) in cell culture and kill HIV-1-infected lymphocytes through natural killer (NK) engagement. These antibodies target the CD4-binding site, the glycans/V3 and V1/V2 loops on gp120, or the gp41 moiety. The landscape of Env epitope exposure at the surface and the sensitivity of infected cells to ADCC vary considerably between viral strains. Efficient ADCC requires sustained cell surface binding of bNAbs to Env, and combining bNAbs allows a potent killing activity. Furthermore, reactivated infected cells from HIV-positive individuals expose heterogeneous Env epitope patterns, with levels that are often but not always sufficient to trigger killing by bNAbs. Our study delineates the parameters controlling ADCC activity of bNAbs, and supports the use of the most potent antibodies to clear the viral reservoir. Twit Text FOAVip Elimination of HIV-1-infected cells by broadly neutralizing antibodies ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26936020 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26936020 #FOAvip English Wikipedia <ref>{{Cite pmid|26936020}}</ref> Elimination of HIV-1-infected cells by broadly neutralizing antibodies #MMPMID26936020 Bruel T; Guivel-Benhassine F; Amraoui S; Malbec M; Richard L; Bourdic K; Donahue DA; Lorin V; Casartelli N; Noël N; Lambotte O; Mouquet H; Schwartz O Nat Commun 2016[]; 7 (ä): ä PMID26936020show ga The Fc region of HIV-1 Env-specific broadly neutralizing antibodies (bNAbs) is required for suppressing viraemia, through mechanisms which remain poorly understood. Here, we identify bNAbs that exert antibody-dependent cellular cytotoxicity (ADCC) in cell culture and kill HIV-1-infected lymphocytes through natural killer (NK) engagement. These antibodies target the CD4-binding site, the glycans/V3 and V1/V2 loops on gp120, or the gp41 moiety. The landscape of Env epitope exposure at the surface and the sensitivity of infected cells to ADCC vary considerably between viral strains. Efficient ADCC requires sustained cell surface binding of bNAbs to Env, and combining bNAbs allows a potent killing activity. Furthermore, reactivated infected cells from HIV-positive individuals expose heterogeneous Env epitope patterns, with levels that are often but not always sufficient to trigger killing by bNAbs. Our study delineates the parameters controlling ADCC activity of bNAbs, and supports the use of the most potent antibodies to clear the viral reservoir. äElimination of HIV-1-infected cells by broadly neutralizing antibodies(epmc).pdf DeepDyve Pubget Overpricing