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10.1101/gad.276790.115

http://scihub22266oqcxt.onion/10.1101/gad.276790.115
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C4782046!4782046!26944678
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suck abstract from ncbi


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pmid26944678      Genes+Dev 2016 ; 30 (5): 508-21
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  • UTX inhibition as selective epigenetic therapy against TAL1-driven T-cell acute lymphoblastic leukemia #MMPMID26944678
  • Benyoucef A; Palii CG; Wang C; Porter CJ; Chu A; Dai F; Tremblay V; Rakopoulos P; Singh K; Huang S; Pflumio F; Hébert J; Couture JF; Perkins TJ; Ge K; Dilworth FJ; Brand M
  • Genes Dev 2016[Mar]; 30 (5): 508-21 PMID26944678show ga
  • Benyoucef et al. reveal the existence of a subtype-specific epigenetic vulnerability in T-cell acute lymphoblastic leukemia (T-ALL) by which a particular subgroup of T-ALL characterized by expression of the oncogenic transcription factor TAL1 is uniquely sensitive to variations in the dosage and activity of the histone 3 Lys27 (H3K27) demethylase UTX/KDM6A.
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