Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=27013948
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Corpora Amylacea of Brain Tissue from Neurodegenerative Diseases Are Stained with
Specific Antifungal Antibodies
#MMPMID27013948
Pisa D
; Alonso R
; Rábano A
; Carrasco L
Front Neurosci
2016[]; 10
(?): 86
PMID27013948
show ga
The origin and potential function of corpora amylacea (CA) remains largely
unknown. Low numbers of CA are detected in the aging brain of normal individuals
but they are abundant in the central nervous system of patients with
neurodegenerative diseases. In the present study, we show that CA from patients
diagnosed with Alzheimer's disease (AD) contain fungal proteins as detected by
immunohistochemistry analyses. Accordingly, CA were labeled with different
anti-fungal antibodies at the external surface, whereas the central portion
composed of calcium salts contain less proteins. Detection of fungal proteins was
achieved using a number of antibodies raised against different fungal species,
which indicated cross-reactivity between the fungal proteins present in CA and
the antibodies employed. Importantly, these antibodies do not immunoreact with
cellular proteins. Additionally, CNS samples from patients diagnosed with
amyotrophic lateral sclerosis (ALS) and Parkinson's disease (PD) also contained
CA that were immunoreactive with a range of antifungal antibodies. However, CA
were less abundant in ALS or PD patients as compared to CNS samples from AD. By
contrast, CA from brain tissue of control subjects were almost devoid of fungal
immunoreactivity. These observations are consistent with the concept that CA
associate with fungal infections and may contribute to the elucidation of the
origin of CA.
free
free
free
