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2015 ; 19
(62
): 1-62
Nephropedia Template TP
gab.com Text
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English Wikipedia
Diagnostic accuracy of the Thessaly test, standardised clinical history and other
clinical examination tests (Apley s, McMurray s and joint line tenderness) for
meniscal tears in comparison with magnetic resonance imaging diagnosis
#MMPMID26243431
Blyth M
; Anthony I
; Francq B
; Brooksbank K
; Downie P
; Powell A
; Jones B
; MacLean A
; McConnachie A
; Norrie J
Health Technol Assess
2015[Aug]; 19
(62
): 1-62
PMID26243431
show ga
BACKGROUND: Reliable non-invasive diagnosis of meniscal tears is difficult.
Magnetic resonance imaging (MRI) is often used but is expensive and incidental
findings are problematic. There are a number of physical examination tests for
the diagnosis of meniscal tears that are simple, cheap and non-invasive.
OBJECTIVES: To determine the diagnostic accuracy of the Thessaly test and to
determine if the Thessaly test (alone or in combination with other physical
tests) can obviate the need for further investigation by MRI or arthroscopy for
patients with a suspected meniscal tear. DESIGN: Single-centre prospective
diagnostic accuracy study. SETTING: Although the study was performed in a
secondary care setting, it was designed to replicate the results that would have
been achieved in a primary care setting. PARTICIPANTS: Two cohorts of patients
were recruited: patients with knee pathology (n?=?292) and a control cohort with
no knee pathology (n?=?75). MAIN OUTCOME MEASURES: Sensitivity, specificity and
diagnostic accuracy of the Thessaly test in determining the presence of meniscal
tears. METHODS: Participants were assessed by both a primary care clinician and a
musculoskeletal clinician. Both clinicians performed the Thessaly test,
McMurray's test, Apley's test, joint line tenderness test and took a standardised
clinical history from the patient. RESULTS: The Thessaly test had a sensitivity
of 0.66, a specificity of 0.39 and a diagnostic accuracy of 54% when utilised by
primary care clinicians. This compared with a sensitivity of 0.62, a specificity
of 0.55 and diagnostic accuracy of 59% when used by musculoskeletal clinicians.
The diagnostics accuracy of the other tests when used by primary care clinicians
was 54% for McMurray's test, 53% for Apley's test, 54% for the joint line
tenderness test and 55% for clinical history. For primary care clinicians, age
and past history of osteoarthritis were both significant predictors of MRI
diagnosis of meniscal tears. For musculoskeletal clinicians age and a positive
diagnosis of meniscal tears on clinical history taking were significant
predictors of MRI diagnosis. No physical tests were significant predictors of MRI
diagnosis in our multivariate models. The specificity of MRI diagnosis was tested
in subgroup of patients who went on to have a knee arthroscopy and was found to
be low [0.53 (95% confidence interval 0.28 to 0.77)], although the sensitivity
was 1.0. CONCLUSIONS: The Thessaly test was no better at diagnosing meniscal
tears than other established physical tests. The sensitivity, specificity and
diagnostic accuracy of all physical tests was too low to be of routine clinical
value as an alternative to MRI. Caution needs to be exercised in the
indiscriminate use of MRI scanning in the identification of meniscal tears in the
diagnosis of the painful knee, due to the low specificity seen in the presence of
concomitant knee pathology. Further research is required to determine the true
diagnostic accuracy and cost-effectiveness of MRI for the detection of meniscal
tears. TRIAL REGISTRATION: Current Controlled Trial ISRCTN43527822. FUNDING: The
National Institute for Health Research Health Technology Assessment programme.