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10.1021/jacs.5b06770 http://scihub22266oqcxt.onion/10.1021/jacs.5b06770 C4780671!4780671!26266881     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Am+Chem+Soc 2015 ; 137 (34): 10867-9 Nephropedia Template TP {{tp|p=26266881|t=2015. New Insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1 |pdf=|usr=}}{{26266881}} gab.com Text New Insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1 JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=26266881 #FOAvip A crucial and enigmatic step in the complex biosynthesis of aflatoxin B1 is the oxidative rearrangement of versicolorin A to demethylsterigmatocystin. This step is thought to proceed by an oxidation?reduction?oxidation sequence, in which the NADPH-dependent oxidoreductase AflM catalyzes the enclosed reduction step. AflM from Aspergillus parasiticus, after heterologous production in E. coli and puriflcation, however, catalyzed the reduction of the hydroquinoid form of the starting compound versicolorin A (25% conversion) to a so far unknown product of aflatoxin biosynthesis. The asymmetric reduction of emodin hydroquinone to (R)-3,8,9,10-tetrahydroxy-6-methyl-3,4-dihydroanthracen-1(2H)-one (up to 82% for AflM) has also been observed in previous studies using MdpC from Aspergillus nidulans (mono-dictyphenone biosynthetic gene cluster). The first (non-enzymatic) reduction of emodin to emodin hydroquinone, for example with sodium dithionite, is obligatory for the enzymatic reduction by AflM or MdpC. These results imply an unprecedented role of AflM in the complex enzymatic network of aflatoxin biosynthesis. Twit Text FOAVip New Insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1 ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=26266881 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26266881 #FOAvip English Wikipedia <ref>{{Cite pmid|26266881}}</ref> New Insights into the Conversion of Versicolorin A in the Biosynthesis of Aflatoxin B1 #MMPMID26266881 Conradt D; Schätzle MA; Haas J; Townsend CA; Müller M J Am Chem Soc 2015[Sep]; 137 (34): 10867-9 PMID26266881show ga A crucial and enigmatic step in the complex biosynthesis of aflatoxin B1 is the oxidative rearrangement of versicolorin A to demethylsterigmatocystin. This step is thought to proceed by an oxidation?reduction?oxidation sequence, in which the NADPH-dependent oxidoreductase AflM catalyzes the enclosed reduction step. AflM from Aspergillus parasiticus, after heterologous production in E. coli and puriflcation, however, catalyzed the reduction of the hydroquinoid form of the starting compound versicolorin A (25% conversion) to a so far unknown product of aflatoxin biosynthesis. The asymmetric reduction of emodin hydroquinone to (R)-3,8,9,10-tetrahydroxy-6-methyl-3,4-dihydroanthracen-1(2H)-one (up to 82% for AflM) has also been observed in previous studies using MdpC from Aspergillus nidulans (mono-dictyphenone biosynthetic gene cluster). The first (non-enzymatic) reduction of emodin to emodin hydroquinone, for example with sodium dithionite, is obligatory for the enzymatic reduction by AflM or MdpC. These results imply an unprecedented role of AflM in the complex enzymatic network of aflatoxin biosynthesis. äNew Insights into the Conversion of Versicolorin A in the Biosynthesis(epmc).pdf DeepDyve Pubget Overpricing