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10.1073/pnas.1525466113 http://scihub22266oqcxt.onion/10.1073/pnas.1525466113 C4780638!4780638!26884167     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (9): E1316-25 Nephropedia Template TP {{tp|p=26884167|t=2016. The adaptive immune system restrains Alzheimer?s disease pathogenesis by modulating microglial function |pdf=|usr=}}{{26884167}} gab.com Text The adaptive immune system restrains Alzheimer s disease pathogenesis by modulating microglial function JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26884167 #FOAvip Neuroinflammation and activation of innate immunity are pathological hallmarks of Alzheimer?s disease (AD). In contrast, very few studies have examined the impact of the adaptive immune system in AD pathogenesis. Here, we find that genetic ablation of peripheral immune cell populations significantly accelerates amyloid pathogenesis, worsens neuroinflammation, and alters microglial activation state. Critically, it appears that loss of IgG-producing B cells impairs microglial phagocytosis, thereby exacerbating amyloid deposition. Conversely, replacement of IgGs via direct injection or bone marrow transplantation reverses these effects and reduces A? pathology. Together, these results highlight the importance of the adaptive immune system and its interactions with microglia in the pathogenesis of AD. Twit Text FOAVip The adaptive immune system restrains Alzheimer s disease pathogenesis by modulating microglial function ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26884167 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26884167 #FOAvip English Wikipedia <ref>{{Cite pmid|26884167}}</ref> The adaptive immune system restrains Alzheimer?s disease pathogenesis by modulating microglial function #MMPMID26884167 Marsh SE; Abud EM; Lakatos A; Karimzadeh A; Yeung ST; Davtyan H; Fote GM; Lau L; Weinger JG; Lane TE; Inlay MA; Poon WW; Blurton-Jones M Proc Natl Acad Sci U S A 2016[Mar]; 113 (9): E1316-25 PMID26884167show ga Neuroinflammation and activation of innate immunity are pathological hallmarks of Alzheimer?s disease (AD). In contrast, very few studies have examined the impact of the adaptive immune system in AD pathogenesis. Here, we find that genetic ablation of peripheral immune cell populations significantly accelerates amyloid pathogenesis, worsens neuroinflammation, and alters microglial activation state. Critically, it appears that loss of IgG-producing B cells impairs microglial phagocytosis, thereby exacerbating amyloid deposition. Conversely, replacement of IgGs via direct injection or bone marrow transplantation reverses these effects and reduces A? pathology. Together, these results highlight the importance of the adaptive immune system and its interactions with microglia in the pathogenesis of AD. äThe adaptive immune system restrains Alzheimer?s disease pathogenesis (epmc).pdf DeepDyve Pubget Overpricing