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10.1073/pnas.1525098113 http://scihub22266oqcxt.onion/10.1073/pnas.1525098113 C4780634!4780634!26869716     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 247.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Proc+Natl+Acad+Sci+U+S+A 2016 ; 113 (9): 2460-5 Nephropedia Template TP {{tp|p=26869716|t=2016. CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity |pdf=|usr=}}{{26869716}} gab.com Text CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity JO: Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26869716 #FOAvip Our study demonstrated that CD8+CD122+CD49dlow regulatory T cells induced apoptosis in target T cells depending on death receptor Fas (CD95)?FasL (CD178) interaction. This in vitro phenomenon reflected the regulatory activity of these cells in vivo, which was also reproducible in the in vivo experimental system of adoptive T-cell transfer. By using natural mutant mice of Fas or FasL and the gene-targeted mice of IL-10, we confirmed that the regulatory activity of CD8+CD122+CD49dlow cells was mediated by Fas?FasL but not by IL-10. In addition, the necessity of MHC class I molecules on the target T cells was also confirmed by analysis using CD8+ T cells that lack ?2-microglobulin and consequently class I MHC. Twit Text FOAVip CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity ????Proc Natl Acad Sci U S A http://www.kidney.de/pget.php?&tw=1&pmid=26869716 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26869716 #FOAvip English Wikipedia <ref>{{Cite pmid|26869716}}</ref> CD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by killing activated T cells via Fas/FasL-mediated cytotoxicity #MMPMID26869716 Akane K; Kojima S; Mak TW; Shiku H; Suzuki H Proc Natl Acad Sci U S A 2016[Mar]; 113 (9): 2460-5 PMID26869716show ga Our study demonstrated that CD8+CD122+CD49dlow regulatory T cells induced apoptosis in target T cells depending on death receptor Fas (CD95)?FasL (CD178) interaction. This in vitro phenomenon reflected the regulatory activity of these cells in vivo, which was also reproducible in the in vivo experimental system of adoptive T-cell transfer. By using natural mutant mice of Fas or FasL and the gene-targeted mice of IL-10, we confirmed that the regulatory activity of CD8+CD122+CD49dlow cells was mediated by Fas?FasL but not by IL-10. In addition, the necessity of MHC class I molecules on the target T cells was also confirmed by analysis using CD8+ T cells that lack ?2-microglobulin and consequently class I MHC. äCD8+CD122+CD49dlow regulatory T cells maintain T-cell homeostasis by k(epmc).pdf DeepDyve Pubget Overpricing