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10.5487/TR.2016.32.1.047 http://scihub22266oqcxt.onion/10.5487/TR.2016.32.1.047 C4780241!4780241!26977258     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Toxicol+Res 2016 ; 32 (1): 47-56 Nephropedia Template TP {{tp|p=26977258|t=2016. Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury |pdf=|usr=}}{{26977258}} gab.com Text Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury JO: Toxicol Res http://www.kidney.de/pget.php?&tw=1&pmid=26977258 #FOAvip The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important. Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidity and mortality. Conventional biomarkers, such as serum creatinine (SCr) and blood urea nitrogen (BUN), are frequently used to diagnose AKI. However, these biomarkers increase only after significant structural damage has occurred. Recent efforts have focused on identification and validation of new noninvasive biomarkers for the early detection of AKI, prior to extensive structural damage. Furthermore, AKI biomarkers can provide valuable insight into the molecular mechanisms of this complex and heterogeneous disease. Our previous study suggested that pyruvate kinase M2 (PKM2), which is excreted in the urine, is a sensitive biomarker for nephrotoxicity. To appropriately and optimally utilize PKM2 as a biomarker for AKI requires its complete characterization. This review highlights the major studies that have addressed the diagnostic and prognostic predictive power of biomarkers for AKI and assesses the potential usage of PKM2 as an early biomarker for AKI. We summarize the current state of knowledge regarding the role of biomarkers and the molecular and cellular mechanisms of AKI. This review will elucidate the biological basis of specific biomarkers that will contribute to improving the early detection and diagnosis of AKI. Twit Text FOAVip Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury ????Toxicol Res http://www.kidney.de/pget.php?&tw=1&pmid=26977258 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26977258 #FOAvip English Wikipedia <ref>{{Cite pmid|26977258}}</ref> Pyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute Kidney Injury #MMPMID26977258 Cheon JH; Kim SY; Son JY; Kang YR; An JH; Kwon JH; Song HS; Moon A; Lee BM; Kim HS Toxicol Res 2016[Jan]; 32 (1): 47-56 PMID26977258show ga The identification of biomarkers for the early detection of acute kidney injury (AKI) is clinically important. Acute kidney injury (AKI) in critically ill patients is closely associated with increased morbidity and mortality. Conventional biomarkers, such as serum creatinine (SCr) and blood urea nitrogen (BUN), are frequently used to diagnose AKI. However, these biomarkers increase only after significant structural damage has occurred. Recent efforts have focused on identification and validation of new noninvasive biomarkers for the early detection of AKI, prior to extensive structural damage. Furthermore, AKI biomarkers can provide valuable insight into the molecular mechanisms of this complex and heterogeneous disease. Our previous study suggested that pyruvate kinase M2 (PKM2), which is excreted in the urine, is a sensitive biomarker for nephrotoxicity. To appropriately and optimally utilize PKM2 as a biomarker for AKI requires its complete characterization. This review highlights the major studies that have addressed the diagnostic and prognostic predictive power of biomarkers for AKI and assesses the potential usage of PKM2 as an early biomarker for AKI. We summarize the current state of knowledge regarding the role of biomarkers and the molecular and cellular mechanisms of AKI. This review will elucidate the biological basis of specific biomarkers that will contribute to improving the early detection and diagnosis of AKI. äPyruvate Kinase M2: A Novel Biomarker for the Early Detection of Acute(epmc).pdf DeepDyve Pubget Overpricing