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10.1038/srep22374

http://scihub22266oqcxt.onion/10.1038/srep22374
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suck abstract from ncbi


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pmid26947764      Sci+Rep 2016 ; 6 (ä): ä
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  • Influence of cyclosporine A on glomerular growth and the effect of mizoribine and losartan on cyclosporine nephrotoxicity in young rats #MMPMID26947764
  • Kim JH; Lee YH; Lim BJ; Jeong HJ; Kim PK; Shin JI
  • Sci Rep 2016[]; 6 (ä): ä PMID26947764show ga
  • The aim of this study was to evaluate the influence of cyclosporine A (CsA) on glomerular growth and the effect of mizoribine (MZR) and losartan (LSAR) on CsA-induced nephropathy in young rats. Six-week-old male Sprague-Dawley rats maintained on a low salt diet were given CsA (15?mg/kg), CsA and LSRT (30?mg/kg/day), CsA and MZR (5?mg/kg), or a combination of CsA, LSRT, and MZR for 4 and 7 weeks (two experiments) and compared with control group (olive oil-treated). Histopathology and glomerular size, inflammatory and fibrotic factors were studied. The score of acute CsA toxicity significantly decreased in the CsA?+?MZR group compared to the CsA group (p?
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