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10.3389/fimmu.2016.00078 http://scihub22266oqcxt.onion/10.3389/fimmu.2016.00078 C4779881!4779881!27014261     free     free     free       Front+Immunol 2016 ; 7 (ä): ä Nephropedia Template TP {{tp|p=27014261|t=2016. Targeting Syk in Autoimmune Rheumatic Diseases |pdf=|usr=}}{{27014261}} gab.com Text Targeting Syk in Autoimmune Rheumatic Diseases JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27014261 #FOAvip Spleen tyrosine kinase (Syk) is a member of the Src family of non-receptor tyrosine kinases, which associates directly with surface receptors, including B-cell receptor and Fc? receptor, and is involved in a variety of signal transduction pathways. Rheumatoid arthritis (RA) and systemic lupus erythematosus are autoimmune diseases in which autoantibodies, immune complexes, and autoreactive T cells account for the expression of tissue inflammation and damage. Syk inhibitors efficiently suppress RA in patients albeit in the expression of unwanted side effects, including gastrointestinal effects, hypertension, and neutropenia. Syk inhibitors also inhibit clinical manifestations in lupus-prone mice. Here, we review the evidence that supports the use of Syk inhibitors to treat rheumatic and other autoimmune diseases. Twit Text FOAVip Targeting Syk in Autoimmune Rheumatic Diseases ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=27014261 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27014261 #FOAvip English Wikipedia <ref>{{Cite pmid|27014261}}</ref> Targeting Syk in Autoimmune Rheumatic Diseases #MMPMID27014261 Deng GM; Kyttaris VC; Tsokos GC Front Immunol 2016[]; 7 (ä): ä PMID27014261show ga Spleen tyrosine kinase (Syk) is a member of the Src family of non-receptor tyrosine kinases, which associates directly with surface receptors, including B-cell receptor and Fc? receptor, and is involved in a variety of signal transduction pathways. Rheumatoid arthritis (RA) and systemic lupus erythematosus are autoimmune diseases in which autoantibodies, immune complexes, and autoreactive T cells account for the expression of tissue inflammation and damage. Syk inhibitors efficiently suppress RA in patients albeit in the expression of unwanted side effects, including gastrointestinal effects, hypertension, and neutropenia. Syk inhibitors also inhibit clinical manifestations in lupus-prone mice. Here, we review the evidence that supports the use of Syk inhibitors to treat rheumatic and other autoimmune diseases. äTargeting Syk in Autoimmune Rheumatic Diseases (epmc).pdf DeepDyve Pubget Overpricing