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10.3978/j.issn.1000-9604.2016.02.09

http://scihub22266oqcxt.onion/10.3978/j.issn.1000-9604.2016.02.09
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suck abstract from ncbi


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pmid27041930
      Chin+J+Cancer+Res 2016 ; 28 (1 ): 80-91
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  • Epigenomics of clear cell renal cell carcinoma: mechanisms and potential use in molecular pathology #MMPMID27041930
  • Xing T ; He H
  • Chin J Cancer Res 2016[Feb]; 28 (1 ): 80-91 PMID27041930 show ga
  • Clear cell renal cell carcinoma (ccRCC) is one frequent form of urologic malignancy with numerous genetic and epigenetic alterations. This review summarizes the recent major findings of epigenetic alterations including DNA methylation, histone modifications, microRNAs and recently identified long noncoding RNAs in the development and progression of ccRCC. These epigenetic profilings can provide a promising means of prognostication and early diagnosis for patients with ccRCCs. With the developed high-throughput technologies nowadays, the epigenetic analyses will have possible clinical applications in the molecular pathology of ccRCC.
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