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10.4049/jimmunol.1502537 http://scihub22266oqcxt.onion/10.4049/jimmunol.1502537 C4779695!4779695!26880765     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Immunol 2016 ; 196 (6): 2526-40 Nephropedia Template TP {{tp|p=26880765|t=2016. T-bet regulates natural Treg afferent lymphatic migration and suppressive function |pdf=|usr=}}{{26880765}} gab.com Text T-bet regulates natural Treg afferent lymphatic migration and suppressive function JO: J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26880765 #FOAvip T-bet is essential for nTreg to regulate Th1 inflammation, but whether T-bet controls other Treg functions after entering the inflammatory site, is unknown. In an islet allograft model, T-bet?/?nTreg but not iTreg failed to prolong graft survival as effectively as wild type Treg. T-bet?/? nTreg had no functional deficiency in vitro but failed to home from the graft to dLN as efficiently as wild type. T-bet regulated expression of adhesion and migration related molecules, influencing nTreg distribution in tissues, so that T-bet?/? nTreg remained in the grafts rather than migrating to lymphatics and dLN. In contrast, both wild type and T-bet?/? CD4+ Tconv and iTreg migrated normally toward afferent lymphatics. T-bet?/? nTreg displayed instability in the graft, failing to suppress antigen-specific CD4+ T cells and prevent their infiltration into the graft and dLN. Thus, T-bet regulates nTreg migration into afferent lymphatics and dLN and consequently their suppressive stability in vivo. Twit Text FOAVip T-bet regulates natural Treg afferent lymphatic migration and suppressive function ????J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26880765 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26880765 #FOAvip English Wikipedia <ref>{{Cite pmid|26880765}}</ref> T-bet regulates natural Treg afferent lymphatic migration and suppressive function #MMPMID26880765 Xiong Y; Ahmad S; Iwami D; Brinkman CC; Bromberg JS J Immunol 2016[Mar]; 196 (6): 2526-40 PMID26880765show ga T-bet is essential for nTreg to regulate Th1 inflammation, but whether T-bet controls other Treg functions after entering the inflammatory site, is unknown. In an islet allograft model, T-bet?/?nTreg but not iTreg failed to prolong graft survival as effectively as wild type Treg. T-bet?/? nTreg had no functional deficiency in vitro but failed to home from the graft to dLN as efficiently as wild type. T-bet regulated expression of adhesion and migration related molecules, influencing nTreg distribution in tissues, so that T-bet?/? nTreg remained in the grafts rather than migrating to lymphatics and dLN. In contrast, both wild type and T-bet?/? CD4+ Tconv and iTreg migrated normally toward afferent lymphatics. T-bet?/? nTreg displayed instability in the graft, failing to suppress antigen-specific CD4+ T cells and prevent their infiltration into the graft and dLN. Thus, T-bet regulates nTreg migration into afferent lymphatics and dLN and consequently their suppressive stability in vivo. äT-bet regulates natural Treg afferent lymphatic migration and suppress(epmc).pdf DeepDyve Pubget Overpricing