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10.1002/eji.201646292 http://scihub22266oqcxt.onion/10.1002/eji.201646292 C4779685!4779685!26846172     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Immunol 2016 ; 46 (3): 539-42 Nephropedia Template TP {{tp|p=26846172|t=2016. A long journey coming to fruition: In sight of the pre-selection T-cell repertoire |pdf=|usr=}}{{26846172}} gab.com Text A long journey coming to fruition: In sight of the pre-selection T-cell repertoire JO: Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26846172 #FOAvip In addition to MHC restriction and its structural correlate, the recognition of an MHC-peptide complex by the T-cell antigen receptor (TCR), T-cell reactivity is constrained by positive and negative selection in the thymus. While mouse genetic studies have provided compelling evidence for both processes, the actual impact of selection on the mature T-cell repertoire has remained difficult to assess, in particular because it has so far not been possible to follow the intrathymic differentiation of antigen-specific T cells carrying endogenous TCR specificities. In this issue of the European Journal of Immunology, Hesnard et al. [Eur. J. Immunol. 2016. 46: XXXX-XXXX] report the detection of human antigen-specific immature thymocytes, thereby opening the way to addressing these questions. Here we discuss the implications of this technological advance. Twit Text FOAVip A long journey coming to fruition: In sight of the pre-selection T-cell repertoire ????Eur J Immunol http://www.kidney.de/pget.php?&tw=1&pmid=26846172 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26846172 #FOAvip English Wikipedia <ref>{{Cite pmid|26846172}}</ref> A long journey coming to fruition: In sight of the pre-selection T-cell repertoire #MMPMID26846172 Ciucci T; Bosselut R Eur J Immunol 2016[Mar]; 46 (3): 539-42 PMID26846172show ga In addition to MHC restriction and its structural correlate, the recognition of an MHC-peptide complex by the T-cell antigen receptor (TCR), T-cell reactivity is constrained by positive and negative selection in the thymus. While mouse genetic studies have provided compelling evidence for both processes, the actual impact of selection on the mature T-cell repertoire has remained difficult to assess, in particular because it has so far not been possible to follow the intrathymic differentiation of antigen-specific T cells carrying endogenous TCR specificities. In this issue of the European Journal of Immunology, Hesnard et al. [Eur. J. Immunol. 2016. 46: XXXX-XXXX] report the detection of human antigen-specific immature thymocytes, thereby opening the way to addressing these questions. Here we discuss the implications of this technological advance. äA long journey coming to fruition: In sight of the pre-selection T-cel(epmc).pdf DeepDyve Pubget Overpricing