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10.1007/s00281-015-0534-0 http://scihub22266oqcxt.onion/10.1007/s00281-015-0534-0 C4779414!4779414!26490974     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Semin+Immunopathol 2016 ; 38 (2): 139-52 Nephropedia Template TP {{tp|p=26490974|t=2016. Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration |pdf=|usr=}}{{26490974}} gab.com Text Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration JO: Semin Immunopathol http://www.kidney.de/pget.php?&tw=1&pmid=26490974 #FOAvip Tuberculosis (TB) granulomas are compact, organized agglomerations of infected and uninfected macrophages, T cells, neutrophils and other immune cells. Within the granuloma, several unique metabolic adaptations occur to modify the behavior of immune cells, potentially favoring bacterial persistence balanced with protection against immunopathology. These include the induction of arginase-1 in macrophages to temper nitric oxide (NO) production and block T cell proliferation, inhibition of oxygen-requiring NO production in hypoxic regions, and induction of tryptophan degrading enzymes that modify T cell proliferation and function. The spatial and time dependent organization of granulomas further influences immunometabolism, for example through lactate production by activated macrophages, which can induce arginase-1. Although complex, the metabolic changes in and around TB granulomas can be potentially modified by host-directed therapies. While elimination of the TB bacilli is often the goal of any anti-TB therapy, host-directed approaches must also account for the possibility of immunopathologic damage to the lung. Twit Text FOAVip Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration ????Semin Immunopathol http://www.kidney.de/pget.php?&tw=1&pmid=26490974 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26490974 #FOAvip English Wikipedia <ref>{{Cite pmid|26490974}}</ref> Immunometabolism within the tuberculosis granuloma: amino acids, hypoxia, and cellular respiration #MMPMID26490974 Qualls JE; Murray PJ Semin Immunopathol 2016[Mar]; 38 (2): 139-52 PMID26490974show ga Tuberculosis (TB) granulomas are compact, organized agglomerations of infected and uninfected macrophages, T cells, neutrophils and other immune cells. Within the granuloma, several unique metabolic adaptations occur to modify the behavior of immune cells, potentially favoring bacterial persistence balanced with protection against immunopathology. These include the induction of arginase-1 in macrophages to temper nitric oxide (NO) production and block T cell proliferation, inhibition of oxygen-requiring NO production in hypoxic regions, and induction of tryptophan degrading enzymes that modify T cell proliferation and function. The spatial and time dependent organization of granulomas further influences immunometabolism, for example through lactate production by activated macrophages, which can induce arginase-1. Although complex, the metabolic changes in and around TB granulomas can be potentially modified by host-directed therapies. While elimination of the TB bacilli is often the goal of any anti-TB therapy, host-directed approaches must also account for the possibility of immunopathologic damage to the lung. äImmunometabolism within the tuberculosis granuloma: amino acids, hypox(epmc).pdf DeepDyve Pubget Overpricing